AI Article Synopsis
- * Our research included looking at both common and rare gene variants connected to the NLRP3 inflammasome, as well as assessing the potential effects of related cytokines (IL-1β and IL-18) on PD.
- * The results showed no significant link between NLRP3 variations and PD, suggesting that the NLRP3 inflammasome may not be a viable target for treatment or play a role in the disease's development.
Article Abstract
Activation of the NLRP3 inflammasome has been implicated in Parkinson's disease (PD) based on in vitro and in vivo studies. Clinical trials targeting the NLRP3 inflammasome in PD are ongoing. However, the evidence supporting NLRP3's involvement in PD from human genetics data is limited. We analyzed common and rare variants in NLRP3 inflammasome-related genes in PD cohorts, performed pathway-specific polygenic risk score (PRS) analyses, and studied causal associations using Mendelian randomization (MR) with the NLRP3 components and the cytokines IL-1β and IL-18. Our findings showed no associations of common or rare variants, nor of the pathway PRS with PD. MR suggests that altering the expression of the NLRP3 inflammasome, IL-1β, or IL-18, does not affect PD risk or progression. Therefore, our results do not support a role for the NLRP3 inflammasome in PD pathogenesis or as a target for drug development.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11300440 | PMC |
| http://dx.doi.org/10.1038/s41531-024-00744-9 | DOI Listing |
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