Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11302499PMC
http://dx.doi.org/10.1523/ENEURO.0264-24.2024DOI Listing

Publication Analysis

Top Keywords

accessible intersectional
4
intersectional transgenic
4
transgenic single-vector
4
single-vector crispr/cas9
4
crispr/cas9 platform
4
platform precise
4
precise gene
4
gene editing
4
editing functional
4
functional analysis
4

Similar Publications

Background: Global health is increasingly burdened by oral diseases (ODs) affecting 3.9 billion people, and Alzheimer's disease with related dementias (AD/ADRD), impacting 46.8 million globally.

View Article and Find Full Text PDF

Developing Topics.

Alzheimers Dement

December 2024

National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA.

Background: Persons with Alzheimer's disease and related dementias (ADRD) have been disproportionally impacted by the COVID-19 pandemic, showing a significantly increased risk of infection and severe illness, including neurocognitive consequences. The National Alzheimer's Coordinating Center collects rich longitudinal, standardized neurocognitive data from populations at high risk of COVID-19 complications, including older adults who were cognitively normal prior to infection and those who had pre-existing ADRD. These data, in combination with Electronic Health Records (EHR) clinic data, will be critical for understanding the complex pathophysiology and cognitive symptoms of COVID-19 and the development of future therapeutics.

View Article and Find Full Text PDF

Background: Dementia, including its younger-onset variant, increasingly challenges diverse workplaces, affecting both employees living with dementia and their employers. With a growing global trend of individuals extending their working years, it becomes crucial to understand the specific challenges and implications for those with dementia within various employment contexts. This review delves into the cognitive, interpersonal, and organizational challenges faced by employees living with dementia across a broad range of workplaces, reflecting the evolving dynamics of today's work environment.

View Article and Find Full Text PDF

Dementia Care Practice.

Alzheimers Dement

December 2024

University of Pennsylvania, Philadelphia, PA, USA.

Background: "Digital health" is a broad term that encompasses a heterogeneous set of scientific concepts and technologies. While digital health tools have the potential to contribute to better health and health care for individuals and communities, they also pose ethical challenges - particularly in the context of Alzheimer's Disease and Alzheimer's Disease and Related Dementias (AD/ADRD). There is no single established ethical framework, however, to aid individuals in evaluating the ethical dimensions of digital health tools in the context of AD/ADRD.

View Article and Find Full Text PDF

Street-connected young people (SCYP) in Tanzania face intersecting challenges, including economic vulnerability, social marginalisation and limited access to supportive networks. This study examines the impact of the Youth Association (YA) model, implemented by Railway Children Africa, and does so through the lens of the relational well-being approach, which emphasises the interplay of material, relational and subjective dimensions of well-being, as well as personal, societal and environmental drivers of well-being. Using a mixed methods design, this study tracked 116 SCYP in Mwanza and Dar es Salaam, Tanzania, through four stages of the YA model.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!