AI Article Synopsis
- The study aimed to evaluate the impact of preoperative chemotherapy on serum zinc levels in patients with pancreatic cancer who underwent surgery between 2013 and 2019.
- Out of 231 patients, those who received chemotherapy showed a significant decrease in serum zinc concentrations after treatment, dropping from 79.3 μg/dl to 68.7 μg/dl.
- The findings suggest that preoperative chemotherapy lowers serum zinc levels consistently across different treatment regimens, highlighting the importance of monitoring zinc levels and considering supplementation for pancreatic cancer patients preparing for surgery.
Article Abstract
Objectives: The aim of this study was to investigate how preoperative chemotherapy affected the serum zinc concentrations in patients with pancreatic cancer (PC).
Methods: Two hundreds and thirty-one patients with PC who underwent pancreatectomy at our department from 2013 to 2019 were enrolled in this study and measured for the serum zinc concentrations before pancreatectomy. Patient characteristics, course of treatment, and laboratory data were analyzed.
Results: One hundred thirty-five patients underwent upfront pancreatectomy and 58 received preoperative Gemcitabine + S1 (GEM + S1) and 29 received Gemcitabine + nab-Paclitaxel (GEM + nab-PTX). Comparing the serum zinc concentrations before and after preoperative treatment, it was found to decrease after treatment with statistical difference (79.3 μg/dl vs. 68.7 μg/dl, p < 0.001). The result was consistent with the investigation for both the patients who received GEM + S1 and those who received GEM + nab-PTX (p = 0.019, p < 0.001, respectively).
Conclusions: The preoperative chemotherapy consistently reduced the serum zinc concentrations in the PC patients, regardless of their regimen such as GEM + S1 and GEM + nab-PTX. Monitoring the serum zinc concentration and appropriate zinc supplementation may be essential for PC patients undergoing preoperative chemotherapy and pancreatectomy.
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| http://dx.doi.org/10.1097/MPA.0000000000002396 | DOI Listing |
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