The exchange of the metal ion from Ni(II) to In(I) leads to a switch in the chemoselectivity of the [3 + 3] annulation of β,γ-unsaturated α-ketoesters and 1pyrazol-5-amines in the presence of phosphoric acid , affording functionalized 1pyrazolo[3,4-]pyridines in up to 97% yields and highly enantioselective 4,5-dihydro-1-pyrazolo[3,4-]pyridines in up to 92% yield and 99% ee.
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