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Intranasal Trans-Mucosal Sphenopalatine Ganglion Block in the Management of Headaches and Facial Pain in Palliative Patients: A Patient Satisfaction and Feasibility Study.
J Palliat Med
October 2024
Department of Palliative Care, St Vincent's Private Hospital Brisbane, Brisbane, Australia.
Sublingual vs. intranasal dexmedetomidine sedation for flexible fiberoptic bronchoscopy procedure: a retrospective comparative study.
Eur Rev Med Pharmacol Sci
December 2023
Thoracic Surgery Department, Faculty of Medicine, Trakya University, Edirne, Turkey.
Objective: Flexible fiberoptic bronchoscopy (FOB) is an often-employed invasive method in diagnosing, staging, and treating lung diseases. Conventional sedative agents facilitate this process. Dexmedetomidine (DM) has low side effects and is easy to administer for trans-mucosal absorption.
View Article and Find Full Text PDFFormulation and evaluation of niosomal vesicles containing ondansetron HCL for trans-mucosal nasal drug delivery.
Drug Dev Ind Pharm
May 2020
Department of Pharmaceutics and Industrial Pharmacy, Military Medical Academy, Cairo, Egypt.
Ondansetron HCl is a (5-HT3) serotonin receptor antagonist, used as anti-emetic drug in combination with anticancer agents. Conventional dosage forms have poor bioavailability and patient compliance. These problems can be reduced by the use of nasal niosomal thermo-reversible gelling system.
View Article and Find Full Text PDFOxymetazoline Applied Topically to the Nasal Mucosa Decreases Trans-Mucosal Nitrous Oxide Exchange for the Middle Ear.
Ann Otol Rhinol Laryngol
May 2016
Department of Otolaryngology, School of Medicine of the University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Objective: Determine if the middle ear (ME) trans-mucosal nitrous oxide (N2O) gas exchange rate can be pharmacologically modulated by the nasal application of a vasoconstrictor.
Methods: In a randomized, double-blind, crossover study, 20 adults received a nasal spray challenge containing either oxymetazoline or saline (placebo). At each session, subjects were fitted with a non-rebreathing mask and breathed room air for 20 minutes, 50% N2O:50% O2 for 20 minutes, and 100% O2 for 10 minutes.
Polymeric penetration enhancers promote humoral immune responses to mucosal vaccines.
J Control Release
June 2014
Imperial College London, Department of Infectious Diseases, Division of Medicine, Norfolk Place, London W2 1PG, UK. Electronic address:
Protective mucosal immune responses are thought best induced by trans-mucosal vaccination, providing greater potential to generate potent local immune responses than conventional parenteral vaccination. However, poor trans-mucosal permeability of large macromolecular antigens limits bioavailability to local inductive immune cells. This study explores the utility of polymeric penetration enhancers to promote trans-mucosal bioavailability of insulin, as a biomarker of mucosal absorption, and two vaccine candidates: recombinant HIV-1 envelope glycoprotein (CN54gp140) and tetanus toxoid (TT).
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