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http://dx.doi.org/10.18632/oncotarget.28573 | DOI Listing |
FEBS Open Bio
December 2024
Y. Xu, Y. Gao, Z.
View Article and Find Full Text PDFOncotarget
August 2024
Department of Intensive Care Unit, Shandong Provincial Third Hospital, Jinan, Shandong, China.
Oncotarget
August 2024
Department of General Surgery, Qilu Hospital of Shandong University, Jinan, P.R. China.
Transl Neurodegener
February 2024
Department of Chemistry, School of Sciences, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15772, Athens, Greece.
Background: It is now realized that Parkinson's disease (PD) pathology extends beyond the substantia nigra, affecting both central and peripheral nervous systems, and exhibits a variety of non-motor symptoms often preceding motor features. Neuroinflammation induced by activated microglia and astrocytes is thought to underlie these manifestations. α-Synuclein aggregation has been linked with sustained neuroinflammation in PD, aggravating neuronal degeneration; however, there is still a lack of critical information about the structural identity of the α-synuclein conformers that activate microglia and/or astrocytes and the molecular pathways involved.
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