AI Article Synopsis
- - The case report analyzes mucocutaneous leishmaniasis in HIV-positive and HIV-negative patients in Brazil, focusing on clinical presentation, diagnosis, treatment, and outcomes.
- - It highlights the unique patterns of oral lesions in Brazil compared to other regions, where oral involvement is usually linked with more severe visceral leishmaniasis in immunocompromised patients.
- - The findings stress the significance of understanding regional differences and the immune status of patients in the diagnosis and treatment of this neglected infectious disease.
Article Abstract
Purpose: This case report examines the clinical presentation, diagnosis, treatment, and outcomes of mucocutaneous leishmaniasis with primary oral involvement in HIV-positive and HIV-negative patients diagnosed in Brazil.
Methods: We discuss the clinical manifestations, diagnostic methods, and therapeutic strategies, highlighting the clinical and histopathologic diagnostic features and distinct progression patterns based on HIV status. Our findings are compared with patterns observed in other countries, emphasizing the differences between the Americas and Europe, Asia, and Africa.
Results: In the Americas, particularly in Brazil, mucocutaneous leishmaniasis often presents with localized oral lesions, even in the presence of systemic immunosuppression, whereas in the Europe, Asia, and Africa, oral involvement is typically associated with visceral leishmaniasis in immunocompromised patients. These differences were due to variations in the parasite species involved.
Conclusion: This comparison underscores the importance of regional and immunological factors in diagnosing and managing this neglected infectious disease.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11300730 | PMC |
| http://dx.doi.org/10.1007/s12105-024-01674-x | DOI Listing |
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