Cladoic Acid, an Anti- Polyketide from sp. TP-F2020.

A new polyketide, cladoic acid, was isolated from a fungus of the genus . The structure of the highly oxygenated -decalin ring with an all- triene side chain was elucidated by extensive spectroscopic analysis. The unique chair/twist-boat conformation of the -decalin core and the flexibility of the B-ring were demonstrated by computer-aided conformational analysis. Cladoic acid was active against and inhibited the proliferation of amastigotes and epimastigotes with IC values of 27 and 46 μM, respectively, but it did not show any appreciable activity against P388 murine leukemia cells, bacteria, or fungi, indicating it is a potential candidate for drug development against Chagas disease.