Shigellosis is an enteric infection that transmits through the faecal-oral route, which can occur during sex between men who have sex with men (MSM). Between 2009 and 2014, an epidemic of sexually transmissible 3a occurred in England that subsequently declined. However, from 2019 to 2021, despite SARS-CoV-2 restrictions, 3a continued to re-emerge. We explored possible drivers of re-emergence by comparing host demography and pathogen genomics. Cases were primarily among 35-64 year old men in London. Genomic analyses of 502 bacterial isolates showed that the majority (58%) of re-emerging MSM strains were a clonal replacement of the original, with reduced antimicrobial resistance, conservation of plasmid col156_1, and two SNPs with 19 predicted effects. The absence of major changes in the pathogen or host demographics suggest that other factors may have driven the re-emergence of 3a and highlight the need for further work in the area.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11296952 | PMC |
| http://dx.doi.org/10.1038/s44259-024-00038-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Addressing STIs through managed care: opportunities in Medicaid and beyond.
Am J Manag Care
December 2024
Department of Health Policy and Management, George Washington University School of Public Health, 950 New Hampshire Ave NW, Washington, DC 20037. Email:
The US is facing a growing epidemic of sexually transmitted infections (STIs), with over 2.5 million cases of chlamydia, gonorrhea, and syphilis reported in 2021 and again in 2022. This public health crisis disproportionately affects youth and racial and ethnic minority communities, exacerbating barriers to accessing sexual health services.
View Article and Find Full Text PDFWhen is it a sexually transmitted infection? Intimate contact transmission of pathogens not traditionally defined as STIs.
Curr Opin Infect Dis
February 2025
Infectious Diseases Unit, Vita-Salute San Raffaele University.
Purpose Of Review: Several microorganisms, which are not traditionally considered sexually transmitted infections (STIs), are capable of sexual transmission and have the potential to cause global outbreaks. The aim of this review is to describe pathogens which are not traditionally defined as STIs, to grant insight on current and potential outbreaks and call for clinical vigilance among members of key populations.
Recent Findings: Recent findings emphasize that several pathogens, not traditionally classified as STIs, can be sexually transmissible.
Background And Aim: In 2022, the monkeypox (mpox) outbreak was declared a public health emergency of international concern. The emergence of a new strain in the Democratic Republic of the Congo and its identification with neighboring countries led to the declaration of a public health emergency in 2024. The objective is to focus on the recent outbreak that led to its declaration as a Public Health Emergency of International Concern, assess the significant global public health threat posed by the newly identified class, and explore effective strategies to address this situation.
View Article and Find Full Text PDFBovine trichomoniasis: A hidden threat to reproductive efficiency.
Open Vet J
November 2024
Research Center for Preclinical and Clinical Medicine, National Research and Innovation Agency (BRIN), Bogor, Indonesia.
Bovine trichomoniasis is a reproductive illness that affects cattle causing pyometra, early to mid-pregnancy miscarriages, and lower birth rates. is a flagellated protozoan which first discovered in France in 1888 and composts three phases during its lifecycle including trophozoite, cyst, and pseudocyst. In addition, several factors contributed to the prevalence of trichomoniasis and fall into three categories are management, cow, and bull-related factors.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!