AI Article Synopsis
- The study identifies specific host factors, such as TRIM28, TRIM33, EHMT1, and EHMT2, that are crucial for SARS-CoV-2 infection by using CRISPR-Cas9 screening.
- TRIM28 may help with the formation of viral particles, while TRIM33, EHMT1, and EHMT2 are likely involved in the virus's transcription and replication processes.
- The compound UNC0642, which inhibits the activity of EHMT1/2, demonstrated significant potential in reducing SARS-CoV-2 growth and disease severity in test models.
Article Abstract
Although many host factors important for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been reported, the mechanisms by which the virus interacts with host cells remain elusive. Here, we identified tripartite motif containing (TRIM) 28, TRIM33, euchromatic histone lysine methyltransferase (EHMT) 1, and EHMT2 as proviral factors involved in SARS-CoV-2 infection by CRISPR-Cas9 screening. Our result suggested that TRIM28 may play a role in viral particle formation and that TRIM33, EHMT1, and EHMT2 may be involved in viral transcription and replication. UNC0642, a compound that specifically inhibits the methyltransferase activity of EHMT1/2, strikingly suppressed SARS-CoV-2 growth in cultured cells and reduced disease severity in a hamster infection model. This study suggests that EHMT1/2 may be a therapeutic target for SARS-CoV-2 infection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11295705 | PMC |
| http://dx.doi.org/10.1016/j.isci.2024.110475 | DOI Listing |
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