AI Article Synopsis
- Mesenchymal stem cells (MSCs) show great potential as candidates for new drugs due to their immune regulation and ability to target tumors.
- They are being researched for applications in cancer therapy and treatment of inflammatory and fibrotic diseases.
- The review discusses various strategies for using MSCs in drug delivery and highlights current limitations and challenges in getting stem cell therapies into clinical use.
Article Abstract
In recent years, cell therapy has provided desirable properties for promising new drugs. Mesenchymal stem cells are promising candidates for developing genetic engineering and drug delivery strategies due to their inherent properties, including immune regulation, homing ability and tumor tropism. The therapeutic potential of mesenchymal stem cells is being investigated for cancer therapy, inflammatory and fibrotic diseases, among others. Mesenchymal stem cells are attractive cellular carriers for synthetic nanoparticles for drug delivery due to their inherent homing ability. In this review, we comprehensively discuss the various genetic and non-genetic strategies of mesenchymal stem cells and their derivatives in drug delivery, tumor therapy, immune regulation, tissue regeneration and other fields. In addition, we discuss the current limitations of stem cell therapy and the challenges in clinical translation, aiming to identify important development areas and potential future directions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11294097 | PMC |
| http://dx.doi.org/10.3389/fimmu.2024.1421854 | DOI Listing |
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