In this work, a one-pot multicomponent synthesis of the ibuprofen-loaded FeO nanoparticles-supported zeolitic imidazolate framework-8 (Ibu-ZIF-8/FeO NPs) nanohybrid was carried out. The ZIF-8/FeO NPs nanohybrid was used as a drug carrier for the release of ibuprofen in a PBS solution. The structure and morphology of the synthesized materials were investigated by powder X-ray diffraction (PXRD) analysis, transmission electron microscopy (TEM) analysis, UV-visible absorption studies, FTIR spectroscopy, and thermogravimetric analysis (TGA). The ibuprofen release kinetics was studied by UV-visible spectroscopy. The mechanism of drug delivery was thoroughly investigated and the Higuchi model was found as the best-fitted model for the ibuprofen release study. The 20 wt % FeO NPs-supported ZIF-8 nanohybrid exhibited more than 95% ibuprofen release efficiency in phosphate buffer saline of pH 7.4 within 2 h. The separation ability of the nanohybrid was very good, and it was easily separated by a simple commercial magnet. In order to investigate the cell viability, the cytotoxicity of ZIF-8, FeO NPs, and ZIF-8/20 wt % FeO NPs was investigated using MTT assays against promastigotes. The ZIF-8/20 wt % FeO NPs nanohybrid carrier exhibited a cell growth inhibition effect with a high correlation coefficient and low probability () values. The high release of drug molecules may be due to the more open site of the ZIF-8/FeO NPs nanohybrid. The drug release profile suggests that the nanohybrid can be potentially used as a drug carrier for targeted drug delivery systems.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11292841 | PMC |
| http://dx.doi.org/10.1021/acsomega.3c09135 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enhanced catalytic transfer hydrogenation of p-nitrophenol using formaldehyde: MnO-supported Ag nanohybrids with tuned d-band structure.
J Colloid Interface Sci
January 2025
Hubei Key Laboratory of Biomass Fibers and Eco-dyeing & Finishing, School of Chemistry and Chemical Engineering, Wuhan Textile University, Wuhan 430200, PR China. Electronic address:
Article Synopsis
- The catalytic reduction of p-nitrophenol (4-NP) to p-aminophenol (4-AP) is essential in the pharmaceutical and agrochemical sectors, with sustainable methods being a priority.
- Using manganese dioxide (MnO) supported silver (Ag) nanoparticles (NPs) as a catalyst for the catalytic transfer hydrogenation (CTH) of 4-NP with formaldehyde (HCHO) provides a safer and more efficient alternative due to lower toxicity and easy handling.
- The study shows that electron transfer from Ag to MnO enhances HCHO activation, resulting in a more effective CTH process, with the optimized 15% Ag/MnO catalyst achieving a significant turnover frequency of 3.83
Innovative auxin-micronutrient based nanocomposites (IAA-FeONPs and IAA-MnONPs) shield strawberry plants from lead toxicity.
Plant Physiol Biochem
December 2024
Department of Pomology, Faculty of Agriculture, Assiut University, Assiut, 71526, Egypt; Biology Research & Studies Institute, Assiut University, Assiut, 71526, Egypt. Electronic address:
Smart nanohybrid technology with potential advantages to plants has recently been developed formanaging the widespread pollution of heavy metals. Herein, we disclose a novel strategy to combat Pb stress in strawberry (Fragaria spp. cv.
View Article and Find Full Text PDFdeveloped NiCoO-TiCT nanohybrid towards non-enzymatic electrochemical detection of glucose and hydrogen peroxide.
J Mater Chem B
December 2024
Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology (VIT), Vellore-632014, India.
Owing to the adverse consequences of excess glucose (Glu) and hydrogen peroxide (HO) on humans, it is imperative to develop an electrochemical sensor for detection of these analytes with good selectivity and sensitivity. Herein, a nanohybrid comprising nickel cobaltite nanoparticles (NiCoO NPs) embedded on conductive TiCT nanosheets (NSs) has been prudently designed and employed for the electrochemical detection of Glu and HO. The developed nanohybrid has been systematically characterized using morphological and spectral techniques, and then immobilized on a glassy carbon electrode (GCE).
View Article and Find Full Text PDFNbCTx-supported bimetallic NPs@ZIF-8 nanohybrid as ECL signal amplifier and peroxidase mimics for chromogranin a immunosensing in human serum and saliva.
Int J Biol Macromol
January 2025
Biosensor and nanobiotechnology Laboratory, Integrated Science Building, Faculty of Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong BE1410, Brunei Darussalam. Electronic address:
Niobium carbide (NbCTx), a key component of the MXene family renowned for its utilization in lithium-ion batteries and supercapacitors, remains largely underutilized in biosensing applications. This study introduces a notably sensitive and label-free dual-mode electrochemiluminescence (ECL) and colorimetric immunosensor to specifically detect chromogranin A (CgA) in biological fluids. Initially, AuAg bimetallic nanoparticles (BiMNPs) were synthesized using NbCTx as a reducing and supporting material.
View Article and Find Full Text PDFDual-Enhanced Nanohybrids for Synergistic Photothermal and Photodynamic Therapy in Cancer Treatment with Immune Checkpoint Inhibitors.
Adv Healthc Mater
November 2024
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea.
Article Synopsis
- This study introduces a nanohybrid designed to enhance both photothermal and photodynamic effects for treating cancer, combining various polymers and gold nanoparticles.
- The unique assembly method produces uniform nanoparticles quickly and effectively, showing potent results when activated by a single near-infrared wavelength.
- The nanohybrid not only inhibits tumor growth and boosts immune responses but also shows improved efficacy when paired with immune checkpoint inhibitors, making it a promising option for combined cancer therapies.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!