AI Article Synopsis

  • Oral administration of celecoxib, an insoluble drug, requires high doses that may elevate cardiovascular risk, making improved delivery methods necessary for patient safety.
  • The study developed hyaluronic acid-modified nanostructured lipid carriers (HA-NLCs) to enhance celecoxib's bioavailability and minimize adverse reactions while establishing FDA-compliant testing methods for pharmacokinetics.
  • Results showed HA-NLCs improved drug absorption by 1.54 times compared to the standard formulation (Celebrex) and increased the drug's retention time and half-life, thereby reducing cardiovascular risks.

Article Abstract

Purpose: Oral drug administration is the most common and convenient route, offering good patient compliance but drug solubility limits oral applications. Celecoxib, an insoluble drug, requires continuous high-dose oral administration, which may increase cardiovascular risk. The nanostructured lipid carriers prepared from drugs and lipid excipients can effectively improve drug bioavailability, reduce drug dosage, and lower the risk of adverse reactions.

Methods: In this study, we prepared hyaluronic acid-modified celecoxib nanostructured lipid carriers (HA-NLCs) to improve the bioavailability of celecoxib and reduce or prevent adverse drug reactions. Meanwhile, we successfully constructed a set of FDA-compliant biological sample test methods to investigate the pharmacokinetics of HA-NLCs in rats.

Results: The pharmacokinetic analysis confirmed that HA-NLCs significantly enhanced drug absorption, resulting in an 1.54 times higher than the reference formulation (Celebrex). Moreover, compared with unmodified nanostructured lipid carriers (CXB-NLCs), HA-NLCs enhance the retention time and improve the drug's half-life in vivo.

Conclusion: HA-NLCs significantly increased the bioavailability of celecoxib. The addition of hyaluronic acid prolonged the drug's in vivo duration of action and reduced the risk of cardiovascular adverse effects associated with the frequent administration of oral celecoxib.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11296516PMC
http://dx.doi.org/10.2147/DDDT.S461969DOI Listing

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