AI Article Synopsis
- Burkitt lymphoma is a type of aggressive B-cell non-Hodgkin lymphoma that can present as a rare solitary lesion in the central nervous system (CNS), which is also linked to acute sudden blindness.
- A case study describes a four-year-old boy exhibiting sudden bilateral vision loss, eye proptosis, and other alarming visual symptoms, leading to neuroimaging that revealed a mass at the base of his skull.
- A biopsy confirmed Burkitt lymphoma, and further genetic analysis diagnosed Kabuki syndrome, prompting the start of treatment with steroids and chemotherapy.
Article Abstract
Burkitt lymphoma is an aggressive B-cell non-Hodgkin lymphoma (NHL). Primary CNS lymphoma (PCNSL) is a rare disease, and the subtype of Burkitt lymphoma presenting as a sole CNS lesion is an even rarer diagnosis. Acute sudden blindness is a rare presenting symptom of PCNSL or NHL in general. We present an interesting case of a four-year-old boy with dysmorphic features whose visual examination showed a sudden bilateral loss of vision. There was bilateral eye proptosis and complete ptosis. Extraocular muscles were fixed straight. The pupils were fixed and mid dilated bilaterally and there was grade 3/4 papilledema in both eyes. Neuroimaging showed a mass in the base of the skull, extending to orbits and sinuses. A cervical biopsy of the enlarged lymph nodes was taken and a histopathological diagnosis of Burkitt lymphoma was made. Genetic analysis showed a mutation, and the patient was diagnosed with Kabuki syndrome by a pediatrician, based on characteristic dysmorphic features. Treatment with steroids and chemotherapy was initiated.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11294968 | PMC |
| http://dx.doi.org/10.7759/cureus.63725 | DOI Listing |
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