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| http://dx.doi.org/10.1007/s40670-024-02103-y | DOI Listing |
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ODSEI Chip: An Open 3D Microfluidic Platform for Studying Tumor Spheroid-Endothelial Interactions.
Adv Sci (Weinh)
January 2025
Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, South Korea.
Current in vitro models of 3D tumor spheroids within the microenvironment have emerged as promising tools for understanding tumor progression and potential drug responses. However, creating spheroids with functional vasculature remains challenging in a controlled and high-throughput manner. Herein, a novel open 3D-microarray platform is presented for a spheroid-endothelium interaction (ODSEI) chip, capable of arraying more than 1000 spheroids on top of the vasculature, compartmentalized for single spheroid-level analysis of drug resistance, and allows for the extraction of specific spheroids for further analysis.
View Article and Find Full Text PDFAssessing Bacteriological Profiles and Targeting Resistant Bacterial Superbugs to Develop an Antibiogram Aiding in Antibiotic Selection.
Cureus
December 2024
Department of Pharmacy Practice, Ratnam Institute of Pharmacy, Nellore, IND.
Introduction The success of surgical procedures is becoming more threatened by the advent of multi-drug resistant (MDR) bacterial strains, sometimes known as superbugs. These resistant microorganisms frequently cause post-surgical infections, which raise morbidity, death, and medical expenses. With an emphasis on resistant strains, this seeks to create an antibiogram and a thorough microbiological profile of surgical infections in order to help choose the most effective antimicrobial therapy.
View Article and Find Full Text PDFA human skin-on-a-chip platform for microneedling-driven skin cancer treatment.
Mater Today Bio
February 2025
Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA, 90024, USA.
Skin-on-a-chip models provide physiologically relevant platforms for studying diseases and drug evaluation, replicating the native skin structures and functions more accurately than traditional 2D or simple 3D cultures. However, challenges remain in creating models suitable for microneedling applications and monitoring, as well as developing skin cancer models for analysis and targeted therapy. Here, we developed a human skin/skin cancer-on-a-chip platform within a microfluidic device using bioprinting/bioengineering techniques.
View Article and Find Full Text PDFCeO@CA-074Me Nanoparticles Alleviate Inflammation and Improve Osteogenic Microenvironment by Regulating the CTSB-NLRP3 Signaling Pathway.
Int J Nanomedicine
January 2025
Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, People's Republic of China.
Background: It is well established that the interaction between osteogenesis and inflammation can impact bone tissue regeneration. The use of nanoparticles to treat and alleviate inflammation at the molecular level has the potential to improve the osteogenic microenvironment and serve as a therapeutic approach.
Methods: We have synthesized new hollow cerium oxide nanoparticles and doped with cathepsin B inhibitor (CA-074Me) to create novel CeO@CA-074Me NPs.
ColMA-based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells.
Bioeng Transl Med
January 2025
Translational NanoMedicine Laboratory, Department of Medicine, Surgery and Dentistry University of Salerno Baronissi SA Italy.
The advent of bioprinting has enabled the creation of precise three-dimensional (3D) cell cultures suitable for biomimetic in vitro models. In this study, we developed a novel protocol for 3D printing methacrylated collagen (ColMa, or PhotoCol®) combined with tendon stem/progenitor cells (hTSPCs) derived from human tendon explants. Although pure ColMa has not previously been proposed as a printable hydrogel, this paper outlines a robust and highly reproducible pipeline for bioprinting this material.
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