AI Article Synopsis
- This paper reviews the recent clinical research on sodium-glucose cotransporter inhibitors (SGLTis) for type 2 diabetes patients with heart-related conditions like heart failure and atrial fibrillation.
- The study found that specific SGLTis (like empagliflozin, dapagliflozin, canagliflozin, and tofogliflozin) are safer and more effective compared to SGLT1 inhibitors but emphasizes the need for more rigorous trials due to small sample sizes and limited evidence.
- The findings aim to improve understanding and potential new uses for SGLTis in clinical settings, highlighting the importance of further research.
Article Abstract
In this paper, we concentrate on updating the clinical research on sodium-glucose cotransporter inhibitors (SGLTis) for patients with type 2 diabetes who have heart failure with a preserved injection fraction, acute heart failure, atrial fibrillation, primary prevention of atherosclerotic cardiovascular disease/cardiovascular disease, and acute myocardial infarction. We searched the data of randomized controlled trials and meta-analyses of SGLTis in patients with diabetes from PubMed between January 1, 2020 and April 6, 2024 for our review. According to our review, certain SGLTis (empagliflozin, dapagliflozin, canagliflozin, and tofogliflozin), but not sodium-glucose cotransporter 1 inhibitor (SGLT1i), exhibit relatively superior clinical safety and effectiveness for treating the abovementioned diseases. Proper utilization of SGLTis in these patients can foster clinical improvement and offer an alternative medication option. However, clinical trials involving SGLTis for certain diseases have relatively small sample sizes, brief intervention durations, and conclusions based on weak evidence, necessitating additional data. These findings are significant and valuable for providing a more comprehensive reference and new possibilities for the clinical utilization and scientific exploration of SGLTis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11292321 | PMC |
| http://dx.doi.org/10.4239/wjd.v15.i7.1461 | DOI Listing |
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