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Trends in hospitalization for cardio-renal disease and mortality in people with type 1 diabetes in England, 2009-2019. | LitMetric

AI Article Synopsis

  • The study aimed to evaluate trends in mortality and complications among individuals with type 1 diabetes in England from 2009 to 2019, prior to the COVID-19 pandemic.
  • It analyzed data from the National Diabetes Audit, finding that overall all-cause mortality remained steady, while mortality from cardiovascular and kidney diseases decreased, but there were increased mortality rates from respiratory diseases and dementia in younger and older demographics.
  • Hospitalization rates for cardiovascular issues rose among younger individuals, while they fell for older individuals, indicating a shift in health complications over the studied period.

Article Abstract

Aim: To assess mortality and complication trends in people with type 1 diabetes during the 11 years before the SARS-CoV2 pandemic (2009-2019).

Materials And Methods: Sequential cohorts of people in England with type 1 diabetes aged ≥20 years from the National Diabetes Audit (2006/2007 to 2016/2017) were analysed. Discretized Poisson regression models, adjusted for age, sex, ethnicity, socioeconomic deprivation and duration of diabetes, were used to calculate mortality and hospitalization rates.

Results: Demographic characteristics changed little; average diabetes duration increased. All-cause mortality was unchanged. Cardiovascular and kidney disease mortality declined. Mortality from respiratory disease, diabetes and dementia increased in younger people (aged 20-74 years) as did mortality from liver disease and dementia in the elderly (aged ≥75 years). Younger Asian and Black people had lower all-cause mortality than those of White ethnicity; elderly Mixed, Asian and Black people had lower all-cause mortality. People from more deprived areas had higher all-cause mortality. The deprivation gradient for mortality was steeper at younger ages. In younger people, rates of hospitalization increased for myocardial infarction, stroke, heart failure and kidney disease but only for kidney disease in the elderly. Rates of a composite measure of cardiovascular hospitalizations increased in younger people (rate ratio [RR] 1.07, 95% confidence interval [CI] 1.03-1.11) but declined in the elderly (RR 0.91, 95% CI 0.86-0.95).

Conclusion: Between 2009 and 2019, hospitalizations for cardiovascular disease increased at younger ages (20-74 years) and hospitalizations for kidney disease increased at all ages, but mortality from cardiovascular and kidney disease declined. All-cause mortality rates were unchanged.

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Source
http://dx.doi.org/10.1111/dom.15783DOI Listing

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