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Development and validation of a prediction model for intrapartum fever related to chorioamnionitis in parturients undergoing epidural analgesia.

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December 2024

Department of Anesthesiology, Sichuan Women's and Children's Hospital/Women's and Children's Hospital, Chengdu Medical College, Chengdu, 610000, China.

Intrapartum fever is a common complication in parturients undergoing epidural analgesia (EA), significantly increasing the incidence of maternal and infant complications. This study aims to develop and validate a prediction model for intrapartum fever related to chorioamnionitis (IFTC) in parturients undergoing epidural analgesia. A total of 596 parturients with fever (axillary temperature ≥ 38℃) who received EA from January 2020 to December 2023 were included and randomly assigned to the training set (N = 417) and the validation set (N = 179) according to the ratio of 7:3.

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Age-related impact of phenobarbital in suppressing prenatal alcohol exposure-related seizures in developing rats.

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Howard University College of Medicine, Department of Physiology and Biophysics, Washington, DC 20059, United States. Electronic address:

Prenatal alcohol exposure (PAE) during pregnancy can increase the prevalence of N-methyl-D-aspartate (NMDA)-induced generalized tonic-clonic seizures (GTCSs) in developing rats. However, it is unclear whether phenobarbital (PB) can suppress these PAE-related seizures. To explore this knowledge gap, we investigated the effects of acute PB treatment on NMDA-induced seizures in postpartum rats, prenatally exposed to alcohol on gestational day 18 (GD18), at two developmental stages: day 7 (P7), the equivalent of pre-term neonates, and day 15 (P15), the equivalent of full-term neonates.

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