AI Article Synopsis
- This study reviews existing research on asprosin levels in patients with type 2 diabetes (T2D), metabolic syndrome (MetS), and obesity to explore its potential as a treatment for metabolic-endocrine disorders.
- A systematic analysis of 26 studies found that individuals with T2D, MetS, and obesity had significantly higher asprosin levels compared to those without these conditions.
- The results suggest that asprosin could serve as a biomarker for metabolic disorders, as its levels are notably elevated in T2D, MetS, and obesity patients.
Article Abstract
Background & Aims: Asprosin is a promising candidate for novel treatments for metabolic-endocrine disorders. The objective of this systematic review and meta-analysis was to consolidate the existing evidence regarding asprosin levels in patients diagnosed with type 2 diabetes (T2D), metabolic syndrome (MetS), and obesity.
Methods: Scopus, Embase, PubMed, Ovid/Medline, and Web of Science were systematically searched without restrictions. We only used the standardized mean differences (SMD) with their 95 % confidence intervals (95 % CI) as the effect measure. A random-effects model (DerSimonian and Laird method) was used for the meta-analysis. Risk of bias was assessed with the Newcastle-Ottawa Scale and Newcastle-Ottawa Scale for Cross-Sectional Studies.
Results: Twenty-six studies (n = 3,787) were included in the meta-analysis. Participants with T2D had higher asprosin values than those without T2D (SMD: 1.64; 95 % CI: 1.08-2.21; I = 97 %). Patients with MetS had higher asprosin levels compared to those without MetS (SMD: 0.99; 95 % CI: 0.34-1.64; I = 96 %). Patients with obesity had higher asprosin levels than participants without obesity (SMD: 1.49; 95 % CI: 0.23-2.76; I = 98 %).
Conclusions: Asprosin is significantly higher in patients with either T2D, MetS, or obesity, compared with controls.
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| http://dx.doi.org/10.1016/j.dsx.2024.103095 | DOI Listing |
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