AI Article Synopsis
- Chronic graft-versus-host disease (GvHD) is a major cause of death in patients who receive allogenic stem cell transplants, with the kidney often affected.
- This article discusses a rare case of chronic GvHD that presents as lupus-like symptoms, including immune complex-mediated glomerulonephritis and various autoantibodies.
- The patient successfully underwent intensive immunosuppressive therapy, with mycophenolate mofetil proving more effective than tacrolimus, highlighting the importance of tailored treatment based on disease mechanisms.
Article Abstract
Chronic graft-versus-host disease (GvHD) is the leading cause of late death in allogenic hematopoietic stem cell transplantation recipients, of which the kidney is a potential target. In this article, we report an extremely rare case of chronic GvHD, characterized by immune complex-mediated diffuse proliferative glomerulonephritis and various autoantibodies detected in the serum; it is the first case of lupus-like chronic GvHD reported to date. The patient responded well to intensive immunosuppressive therapy and reached complete remission. Mycophenolate mofetil was more effective than tacrolimus in this case, suggesting that treatment of kidney diseases associated with chronic GvHD should be based on pathogenesis and pathological patterns.
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| http://dx.doi.org/10.1007/s40620-024-01988-7 | DOI Listing |
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