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Examining the Formalin Fixation Method for Maintaining High RNA Quality in Surgical Lung Specimens.
Thorac Cancer
January 2025
Department of Thoracic and Cardiovascular Surgery, Faculty of Medicine, Saga University, Saga, Japan.
Background: Multiplex genetic testing is recommended when treating nonsmall cell lung cancer. A certain percentage of test failures in RNA assays owing to poor surgical specimen quality have been documented, and fixation failure is a possible cause. At our institution, sheet-like fixation is performed to reduce fixation time.
View Article and Find Full Text PDFThe interaction between antithrombin and endothelial heparan sulfate mitigates pulmonary thromboinflammation after trauma and hemorrhagic shock.
Shock
January 2025
The University of Alabama, Birmingham, Department of Surgery and Center for Injury Science, Division of Trauma and Acute Care Surgery, Birmingham, AL.
Introduction: Trauma and hemorrhagic shock (T/HS) are associated with multiple organ injury. Antithrombin (AT) has anti-inflammatory and organ protective activity through its interaction with endothelial heparan sulfate containing a 3-O-sulfate modification. Our objective was to examine the effects of T/HS on 3-O-sulfated (3-OS) heparan sulfate expression and determine whether AT-heparan sulfate interactions are necessary for its anti-inflammatory properties.
View Article and Find Full Text PDFOutpatient Palliative Care and End-of-Life Care Intensity: Linking Massachusetts Cancer Registry with All-Payer Claims.
JNCI Cancer Spectr
January 2025
Division of General Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Background: Early palliative care is associated with better outcomes for patients with advanced-stage cancers. Using a novel data linkage, we assessed outpatient palliative care use before death and its association with end-of-life care intensity and variation across eight provider networks.
Methods: We linked Massachusetts Cancer Registry and the All-Payer Claims Database for individuals with commercial insurance, Medicaid or Medicare Advantage diagnosed with colorectal, lung, prostate, and breast cancers from 2010 through 2013 who died by December 31, 2014.
Food allergy has no negative impact on children's school performance: A Swedish sibling and co-twin control study.
J Allergy Clin Immunol Glob
February 2025
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Background: Food allergy has been shown to negatively impact children's mental health and quality of life. However, its impact on school performance is unknown.
Objective: We aimed to investigate whether food allergy, severe and nonsevere, is associated with school performance when accounting for measured and unmeasured familial factors.
Successful Diagnosis and Management of Superior Orbital Fissure Syndrome Secondary to Lung Adenocarcinoma: A Case Report.
Cancer Manag Res
January 2025
Department of Radiotherapy, Liaocheng Hospital Affiliated to Shandong First Medical University (Liaocheng People's Hospital), Liaocheng, Shandong, People's Republic of China.
Introduction: Superior orbital fissure syndrome (SOFS) is a rare condition that involves damage to multiple structures within the superior orbital fissure, often caused by trauma, inflammation, or tumors. Lung adenocarcinoma, known for its propensity to metastasize, can lead to orbital metastases, which can manifest as SOFS. This case underscores the diagnostic and therapeutic challenges associated with such rare metastatic presentations.
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