AI Article Synopsis
- Hybrid immunity, a combination of past SARS-CoV-2 infection and vaccination, shows strong protection against COVID-19, but its effects on immunocompromised patients like kidney transplant recipients hasn't been fully studied.
- In a study involving 1,114 kidney transplant patients, those with hybrid immunity had significantly lower rates of infection (12.1%) and almost no hospitalizations or deaths, compared to vaccinated-only individuals (36.54% infection rate and some hospitalizations and deaths).
- The findings highlight the importance of hybrid immunity in reducing the risk of COVID-19 infection and severe outcomes in vulnerable populations, indicating a need for tailored health strategies for these patients.
Article Abstract
Hybrid immunity, resulting from a combination of SARS-CoV-2 infection and vaccination, offers robust protection against COVID-19 in the general population. However, its impact on immunocompromised patients remains unexplored. We investigated the effect of hybrid immunity against the Omicron variant in a population of kidney transplant recipients receiving the fourth dose mRNA monovalent vaccination. By extracting data from the clinical records and performing individual interviews, participants were categorized into the hybrid cohort (previously infected and vaccinated individuals) and the vaccine cohort (vaccinated-only individuals). The study comprised 1114 participants, 442 in the hybrid and 672 in the vaccine cohorts. From April 2022 to August 2023, 286 infections, 38 hospitalizations and 9 deaths were reported. The cumulative incidence of infection was 12.1% (95% confidence interval [CI], 9.03-16.03) for the hybrid cohort and 36.54% (95% CI, 32.81-40.54) for the vaccine cohort after 300 days of follow-up. Hybrid immunity was associated to a 72% lower risk of infection (adjusted hazard ratio, 0.28; 95% CI, 0.21-0.38) and a 96% lower risk of hospitalization (adjusted hazard ratio, 0.04; 95% CI, 0.01-0.32). No deaths occurred in the hybrid cohort. Hybrid immunity was associated with a lower incidence of SARS-CoV-2 infection and severe COVID-19, underscoring its importance for risk stratification in this vulnerable patient population.
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| http://dx.doi.org/10.1016/j.ajt.2024.07.028 | DOI Listing |
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