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Pregnant Woman in Outcomes with Prosthetic Heart Valves.
J Cardiovasc Dev Dis
November 2024
Almazov National Medical Research Centre, St. Petersburg 197341, Russia.
Article Synopsis
- This study investigated thrombotic and hemorrhagic complications during pregnancy, delivery, and postpartum in women with prosthetic heart valves (PHV), covering 88 pregnancies from January 2011 to December 2022.
- Of the pregnancies, 79 resulted in live births, with higher miscarriage rates in the mechanical valve prosthesis (MVP) group compared to the biological valve prosthesis (BVP) group, alongside notable thrombotic complications predominantly in the MVP group.
- While effective anti-factor Xa activity control was noted to reduce thrombotic events, the study highlighted a concerning rate of postpartum hemorrhagic complications, suggesting a need for revising anticoagulant therapy protocols.
Perinatal iron deficiency alters the cardiac proteome and mitochondrial function in neonatal offspring.
Am J Physiol Heart Circ Physiol
January 2025
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Iron deficiency (ID) is common during gestation and early infancy and can alter developmental trajectories with lasting consequences on cardiovascular health. Iron plays a critical role in systemic oxygen transport (via hemoglobin) and aerobic respiration (as a component of mitochondrial complexes). Perinatal ID has been shown to cause cardiac dysfunction in neonates, but the mechanisms underlying these changes have not been characterized.
View Article and Find Full Text PDFPatient-Reported Outcomes in Childhood Moyamoya Arteriopathy.
Pediatr Neurol
January 2025
Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address:
Background: Little is known about quality of life, sleep, and mental health in children with moyamoya arteriopathy (MMA). A better understanding of patient-reported outcomes may lead to improved treatment.
Methods: Patients with MMA <26 years old and their caretakers completed validated, age-appropriate questionnaires including the Pediatric Quality of Life (PedsQL) Inventory and Patient-Reported Outcomes Measurement Information System (PROMIS) measuring health-related quality of life, sleep, anxiety, depression, and overall health.
Long-term hypoxia modulates depolarization activation of BK currents in fetal sheep middle cerebral arterial myocytes.
Front Physiol
November 2024
Lawrence D Longo Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, United States.
Introduction: Previous evidence indicates that gestational hypoxia disrupts cerebrovascular development, increasing the risk of intracranial hemorrhage and stroke in the newborn. Due to the role of cytosolic Ca in regulating vascular smooth muscle (VSM) tone and fetal cerebrovascular blood flow, understanding Ca signals can offer insight into the pathophysiological disruptions taking place in hypoxia-related perinatal cerebrovascular disease. This study aimed to determine the extent to which gestational hypoxia disrupts local Ca sparks and whole-cell Ca signals and coupling with BK channel activity.
View Article and Find Full Text PDFFunctional partitioning of sentence processing and emotional prosody in the right perisylvian cortex after perinatal stroke.
Sci Rep
November 2024
Center for Brain Plasticity and Recovery, Georgetown University Medical Center, Georgetown University, Washington, DC, 20057, USA.
In healthy adults different language abilities-sentence processing versus emotional prosody-are supported by the left (LH) versus the right hemisphere (RH), respectively. However, after LH stroke in infancy, RH regions often support both abilities with normal outcomes. This finding raises an important question: How does the functional map of RH regions change to support both emotional prosody and also typically left-lateralized language functions after an early LH stroke? Does sentence processing simply become reflected into RH frontotemporal regions and overlap with emotional prosody processing? Or do these functions overlap less than would be expected with simple mirroring? In the current work we used task fMRI to examine precisely how sentence processing and emotional prosody processing are both organized in the intact RH of individuals who suffered a large LH perinatal arterial ischemic stroke (LHPS participants).
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