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Opioid-related sleep-disordered breathing: correlates and conundrums.
Sleep
November 2024
John D. Dingell VA Medical Center, Medicine Service, Detroit, MI, USA.
Case of buprenorphine-associated central sleep apnea resolving with dose reduction.
J Opioid Manag
September 2022
Medical Director, Center for Innovation & Discovery in Addictions (CIDA), Assistant Professor, Department of Psychiatry & Human Behavior, Jackson, Mississippi. ORCID: https://orcid.org/0000-0002-8845-0182.
Aside from respiratory suppression in overdose, full opioid agonist agents are known to cause sleep-disordered breathing (SDB). The increasing rates of opioid overdose in the United States have led to increasing use of medication-assisted treatments for opioid use disorders. Dose-dependent increase in SDB has been documented with methadone.
View Article and Find Full Text PDFOpioid Use Disorder, Sleep Deficiency, and Ventilatory Control: Bidirectional Mechanisms and Therapeutic Targets.
Am J Respir Crit Care Med
October 2022
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut; and.
Opioid use continues to rise globally. So too do the associated adverse consequences. Opioid use disorder (OUD) is a chronic and relapsing brain disease characterized by loss of control over opioid use and impairments in cognitive function, mood, pain perception, and autonomic activity.
View Article and Find Full Text PDFLess Well-Known Consequences of the Long-Term Use of Opioid Analgesics: A Comprehensive Literature Review.
Drug Des Devel Ther
March 2022
Institute of Medical Sciences, Medical College, University of Rzeszów, Rzeszów, Poland.
Background: The adverse effects of short-term opioid analgesics are well known and acknowledged; however, the spectrum of the sequelae of long-term use seems less clear. Some effects may remain undetected but still have the potential to cause harm and reduce patients' quality of life.
Objective: To review the literature on the adverse effects of long-term opioid therapy.
A Retrospective Review of Opioid Prescribing Practices for At-Risk Pediatric Populations Undergoing Ambulatory Surgery.
J Pediatr Pharmacol Ther
December 2021
Department of Anesthesiology (JJT, MMM), University of Colorado School of Medicine, Children's Hospital Colorado, Aurora, CO.
Objective: Pediatric patients with sleep-disordered breathing (SDB) and obesity are at risk for opioid-induced respiratory depression. Although monitoring in the inpatient setting allows for early recognition of opioid-related adverse events, there is far less vigilance after ambulatory surgery as patients are discharged home. Guidelines for proper opioid dosing in these pediatric subsets have not been established.
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