AI Article Synopsis
- - Testicular germ cell tumors (TGCTs) are rare, making up about 1% of new cancer diagnoses in men, with incidence rates ranging from 7 to 10 per 100,000 in Europe and North America.
- - About 2-5% of men with TGCT have a risk of germ cell neoplasia in situ (GCNIS) in the other testicle, which can develop into cancer in over 50% of cases.
- - The review explores whether routine biopsies of the healthy testicle should be done to check for GCNIS, emphasizing the need for treatment only if it improves patient outcomes without significantly affecting testicular function.
Article Abstract
Testicular germ cell tumors (TGCTs) are an uncommon disease accounting for roughly 1% of newly diagnosed cancers in men worldwide. Incidence rates vary from 7 to 10 per 100000 males in Europe and North America. Approximately 2-5% of patients with unilateral TGCT will also harbor germ cell neoplasia in situ (GCNIS) in the contralateral testicle, which may progress to cancer in at least 50% of individuals. The question of whether routine contralateral testicular biopsy should be performed in patients with testicular cancer to detect the presence of GCNIS remains controversial. Screening and treatment of GCNIS are warranted only if the patient's outcome will be improved and there will be little impact on testicular function. In this review, we evaluate current guideline recommendations and the issues concerning contralateral testicular biopsy. PATIENT SUMMARY: Among men with cancer in one testicle, about 2-5% will also have cells with cancerous potential, called germ cell neoplasia in situ (GCNIS), in the other testicle. This mini-review discusses issues related to routine biopsy of the other testicle and the risk factors and treatment options for GCNIS in men with testicular cancer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.euf.2024.06.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A 10-Year Single Center Analysis: Is There a Need to Reconsider Our Approach to the Management of Neonatal Testicular Torsion?
Cureus
November 2024
Pediatric Surgery, Royal Hospital for Children, Glasgow, GBR.
The management of neonatal testicular torsion lacks consensus. Arguments in favor of emergency bilateral exploration and fixation include a salvage rate and the incidence of bilateral torsion. We performed a retrospective single-center analysis of all cases of neonatal torsion in our unit between 2012 and 2022 to assess whether our data supports this approach and to publish further data on a disease on which there remains a paucity.
View Article and Find Full Text PDFSurgical management of testicular cancer with limited retroperitoneal disease.
Curr Opin Urol
December 2024
Department of Urology, Cantonal Hospital of Lucerne, Lucerne.
Purpose Of Review: Chemotherapy offers excellent long-term survival rates for men with clinical stage II germ cell tumours. However, in this predominantly younger population, chemotherapy is associated with long-term adverse effects. Primary retroperitoneal lymph node dissection (RPLND) may serve as an alternative treatment option, preserving oncological safety while potentially reducing adverse effects in men with limited retroperitoneal disease.
View Article and Find Full Text PDFA rare case of left transverse testicular ectopia in an adult.
Ann Med Surg (Lond)
December 2024
Kathmandu Medical College, Sinamangal, Kathmandu, Nepal.
Introduction And Importance: Transverse testicular ectopia (TTE) is a rare congenital anomaly in which both testes descend into the same inguinal canal and are located in the same hemiscrotum. Diagnosing TTE can be challenging due to its rarity and unusual presentation.
Case Presentation: The authors present a case of a male in his 50s who was diagnosed with left transverse testicular ectopia after presenting with an empty right hemiscrotum and two testes-like masses in the left hemiscrotum.
Transverse Testicular Ectopy and an Incarcerated Inguinal Hernia in a 2-Month-Old Preterm Boy.
European J Pediatr Surg Rep
January 2024
Department of Pediatric Surgery, Ostschweizer Kinderspital, St. Gallen, Switzerland.
Transverse testicular ectopy (TTE) is a rare anomaly in which both testicles descend through the same inguinal canal. Different variants of this anomaly exist, with the most common presenting as two separate spermatic cords and testicular vessel bundles. The management of this condition is challenging, as various factors have to be considered.
View Article and Find Full Text PDFA Unique Case of Bilateral Testicular Tumours: Nonseminomatous Germ Cell Tumour and Contralateral Spermatocytic Tumour 27 Years Apart.
Urol Int
November 2024
Department of Urology, Asklepios Klinik Altona, Hamburg, Germany.
Introduction: Bilateral testicular tumours occur in 3-5% of all cases with testicular neoplasms. In the majority of cases, histology of the two new growths is identical. The time interval between the two neoplastic events rarely exceeds 10 years.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!