AI Article Synopsis
- The study focuses on creating and characterizing nano-emulsion formulations from extracts of the Asparagus plant to enhance their water solubility and therapeutic potential.
- Asparagus extracts contain beneficial compounds but have limited solubility, thus nano-emulsions are developed to improve their antibacterial and anticancer efficacy.
- Results showed nano-emulsions had suitable properties, significantly boosting the antimicrobial and anticancer activities against specific resistant bacteria and cancer cell lines compared to the unprocessed extracts.
Article Abstract
Objective: Preparation and characterization of nano-emulsion formulations for aerial and root parts extracts.
Significance: Genus Asparagus is known for its antimicrobial and anticancer activities, however, freeze dried powder of aqueous - alcoholic extract prepared in this study, exhibited a limited water solubility, limiting its therapeutic application. Thus, encapsulation of its phytochemicals into nano-emulsion is proposed as a solution to improve water solubility, and facilitate its clinical translation.
Methods: the composition of extracts for both aerial and root parts of was identified by HPLC and LC-MS analysis. Nano-emulsion was prepared homogenization where a mixture of Castor oil: phosphate buffered saline (10 mM, pH 7.4): Tween 80: PEG 600 in a ratio of 10: 5: 2.5: 2.5, respectively. Nano-emulsion formulations were characterized for particle size, polydispersity index (PDI), zeta potential, TEM, viscosity and pH. Then, the antibacterial and anticancer activities of nano-emulsion formulations versus their pure plant counterparts was assessed.
Results: The analysis of extracts identified several flavonoids, phenolics, and saponins which were reported to have antimicrobial and anticancer activities. Nano-emulsion formulations were monodispersed with droplet sizes ranging from 80.27 ± 2.05 to 111.16 ± 1.97 nm, and polydispersity index ≤0.3. Nano-emulsion formulations enhanced significantly the antibacterial (multidrug resistant bacteria causing skin and dental soft tissues infections) and anticancer (HuH7, HEPG2, H460 and HCT116) activities compared to their pure plant extract counterparts.
Conclusion: Employing a nano-delivery system as a carrier for phytochemicals might be an effective strategy to enhance their pharmacological activity, overcome their limitations, and ultimately increase their potential for clinical applications.
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Source |
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| http://dx.doi.org/10.1080/03639045.2024.2386001 | DOI Listing |
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