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Disorders of Volume: Core Curriculum 2025.
Am J Kidney Dis
December 2024
Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington; VA Puget Sound Healthcare System, Seattle, Washington.
Historically, the paradigm for all maladies was associated with an imbalance of the 4 humors: blood, black bile, yellow bile, and phlegm. Although our understanding of disease has evolved significantly since the time of Hippocrates, a similar cornerstone of inpatient and ambulatory care involves understanding and correcting imbalances of volume. The kidneys are the principal organs controlling extracellular volume, capable of both sensing and altering salt retention through multiple redundant pathways, including the sympathetic nervous system and the renin-angiotensin-aldosterone system.
View Article and Find Full Text PDFManagement of Graves' upper eyelid retraction (GUER): A review.
Indian J Ophthalmol
December 2024
Hariram Motumal Nasta and Renu Hariram Nasta Ophthalmic Plastic Surgery Service, L.V. Prasad Eye Institute, Hyderabad, Telangana, India.
Graves' disease, a common autoimmune disorder, characteristically presents with upper eyelid retraction, causing significant functional and cosmetic concerns for affected individuals. The management of Graves' upper eyelid retraction has evolved significantly over recent years, with various surgical and non-surgical interventions. An ideal procedure is predictable and easily repeatable.
View Article and Find Full Text PDF[Drift Correction Method of Wastewater Treatment Model Based on Transfer Learning Across Time Scales].
Huan Jing Ke Xue
January 2025
College of Environment and Ecology, Chongqing University, Chongqing 400045, China.
Data is the core foundation of intelligent operation and maintenance, but currently, there is generally insufficient data for wastewater treatment plants, and the status of wastewater treatment systems dynamically evolves with the changes in the internal and external environment. The intelligent operation and maintenance of wastewater plants face difficulties in modeling and model drift caused by system evolution. In response to this issue, the summer and winter seasons with significant differences in wastewater temperature, wastewater quality, and microbial status were selected as typical comparison scenarios.
View Article and Find Full Text PDFParadoxical attenuation of early amyloid-induced cognitive impairment and synaptic plasticity in an aged APP/Tau bigenic rat model.
Acta Neuropathol Commun
December 2024
Department of Pharmacology & Therapeutics, McGill University, McIntyre Medical Building, 3655 Promenade Sir William Osler Room 1210, Montreal, H3G 1Y6, Canada.
The combination of amyloid beta and tau pathologies leads to tau-mediated neurodegeneration in Alzheimer's disease. However, the relative contributions of amyloid beta and tau peptide accumulation to the manifestation of the pathological phenotype in the early stages, before the overt deposition of plaques and tangles, are still unclear. We investigated the longitudinal pathological effects of combining human-like amyloidosis and tauopathy in a novel transgenic rat model, coded McGill-R-APPxhTau.
View Article and Find Full Text PDFFrom bench to bedside: cutting-edge applications of base editing and prime editing in precision medicine.
J Transl Med
December 2024
Institute of Visual Neuroscience and Stem Cell Engineering, Wuhan University of Science and Technology, Wuhan, 430065, China.
CRISPR-based gene editing technology theoretically allows for precise manipulation of any genetic target within living cells, achieving the desired sequence modifications. This revolutionary advancement has fundamentally transformed the field of biomedicine, offering immense clinical potential for treating and correcting genetic disorders. In the treatment of most genetic diseases, precise genome editing that avoids the generation of mixed editing byproducts is considered the ideal approach.
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