AI Article Synopsis
- Researchers developed a long COVID mouse model to explore neutrophil behavior during the recovery phase of COVID-19, filling gaps in knowledge due to the difficulty of studying human lung tissues.
- The study found that neutrophil recruitment and the formation of neutrophil extracellular traps remained active in the lungs for up to 30 days after infection.
- These neutrophil activities were linked to ongoing lung injury, including fibrosis and inflammation, indicating potential long-term effects of COVID-19 on lung health.
Article Abstract
The involvement of neutrophils in the lungs during the recovery phase of coronavirus disease 2019 (COVID-19) is not well defined mainly due to the limited accessibility of lung tissues from COVID-19 survivors. The lack of an appropriate small animal model has affected the development of effective therapeutic strategies. We here developed a long COVID mouse model to study changes in neutrophil phenotype and association with lung injury. Our data shows persistent neutrophil recruitment and neutrophil extracellular trap formation in the lungs for up to 30 days post-infection which correlates with lung fibrosis and inflammation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11295082 | PMC |
| http://dx.doi.org/10.1002/iid3.1343 | DOI Listing |
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