AI Article Synopsis

  • - Contrast-enhanced breast MRI is recommended for high-risk women but has limitations, such as false positives and increased patient anxiety due to hormonal sensitivity and the potential for overdiagnosis.
  • - Breast-targeted PET imaging offers higher specificity and can detect cancers regardless of breast density or hormonal fluctuations, although traditional PET involves high radiation levels, limiting its use in some cases.
  • - A case study using the low-dose Radialis PET imager for a 33-year-old patient highlighted its ability to detect lesions with low metabolic activity; however, it did not reveal any malignant areas in this instance, resulting in surgical interventions for tumor removal.

Article Abstract

Contrast-enhanced breast magnetic resonance imaging (MRI) is currently recommended as a screening tool for high-risk women and has been advocated for women with radiologically dense breast tissue. While breast MRI is acknowledged for its high sensitivity (with an exception for lower-grade ductal carcinoma (DCIS) where emerging techniques like diffusion-weighted imaging offer improvement), its limitations include sensitivity to hormonal changes and a relatively high false-positive rate, potentially leading to overdiagnosis, increased imaging uncertainty, and unnecessary biopsies. These factors can exacerbate patient anxiety and impose additional costs. Molecular imaging with breast-targeted Positron Emission Tomography (PET) has shown the capability to detect malignancy independent of breast density and hormonal changes. Furthermore, breast-targeted PET has shown higher specificity when compared with MRI. However, traditional PET technology is associated with high radiation dose, which can limit its widespread use particularly in repeated studies or for undiagnosed patients. In this case report, we present a clinical application of low-dose breast imaging utilizing a breast-targeted PET camera (Radialis PET imager, Radialis Inc). The case involves a 33-year-old female patient who had multiple enhanced lesions detected on breast MRI after surgical removal of a malignant phyllodes tumor from the right breast. A benign core biopsy was obtained from the largest lesion seen in the left breast. One month after the MRI, 18F-fluorodeoxyglucose (F-FDG) PET imaging session was performed using the Radialis PET Imager. Although the Radialis PET Imager has proven high count sensitivity and the capability to detect breast lesions with low metabolic activity (at a dose similar to mammography), no areas of increased F-FDG uptake were visualized in this particular case. The patient underwent a right-sided nipple-sparing mastectomy and left-sided lumpectomy, with bilateral reconstruction. The excised left breast tissue was completely benign, as suggested by both core biopsy and the PET results. The case presented highlights a promising clinical application of low-dose breast-targeted PET imaging to mitigate the uncertainty associated with MRI while keeping radiation doses within the safe range typically used in X-ray mammography.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11291220PMC
http://dx.doi.org/10.3389/fonc.2024.1405404DOI Listing

Publication Analysis

Top Keywords

breast mri
12
breast-targeted pet
12
radialis pet
12
pet imager
12
breast
11
pet
10
case report
8
breast tissue
8
hormonal changes
8
capability detect
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!