Immunotherapy and the implementation of more aggressive treatment schemes for locally advanced hepatocellular carcinomas have expanded the boundaries of curative options. Because of these advancements, patients who were once considered beyond the aim of a cure are now eligible for liver transplantation and resection.
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http://dx.doi.org/10.3748/wjg.v30.i28.3452 | DOI Listing |
Int J Cardiol
January 2025
Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Padova, Italy. Electronic address:
T wave inversion (TWI) on the electrocardiogram (ECG) is a relatively common finding in athletes. It poses a diagnostic challenge, as it can indicate either a benign physiological pattern or an early sign of serious cardiac pathology. This expert opinion statement provides a comprehensive review of the current understanding of TWI in athletes, emphasizing the importance of its localization, associated clinical features, and demographic factors in guiding its interpretation and management.
View Article and Find Full Text PDFCurr Biol
December 2024
Department of Pharmacology, Vanderbilt Brain Institute, Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA; Department of Anatomy, Cell Biology, & Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address:
Human and non-human primate studies clearly implicate the dorsolateral prefrontal cortex (dlPFC) as critical for advanced cognitive functions. It is thought that intracortical synaptic architectures within the dlPFC are the integral neurobiological substrate that gives rise to these processes. In the prevailing model, each cortical column makes up one fundamental processing unit composed of dense intrinsic connectivity, conceptualized as the "canonical" cortical microcircuit.
View Article and Find Full Text PDFBest Pract Res Clin Anaesthesiol
September 2024
Department of Anaesthesiology, GZA Hospitals, Antwerp, Belgium.
Labour analgesia is a crucial aspect of obstetric anaesthesia, aiming to alleviate pain during childbirth while ensuring maternal and foetal safety. Over the past decade, advancements in labour analgesia techniques have evolved, impacting initiation, maintenance, and outcomes. We emphasize the longstanding importance of epidural analgesia while recognizing the growing significance of combined spinal-epidural and dural puncture epidural techniques for labour initiation.
View Article and Find Full Text PDFJ Cardiovasc Electrophysiol
January 2025
Douala Gyneco-obstetric and Pediatric Hospital/University of Douala, Douala, Cameroon.
Angew Chem Int Ed Engl
January 2025
Research Center for Energy and Environmental Materials, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.
Unveiling the key influencing factors towards electrode/electrolyte interface control is a long-standing challenge for a better understanding of microscopic electrode kinetics, which is indispensable to building up guiding principles for designer electrocatalysts with desirable functionality. Herein, we exemplify the oxygen evolution reaction (OER) via water molecule oxidation with the iridium dioxide electrocatalyst and uncovered the significant mismatching effect of pH between local electrode surface and bulk electrolyte: the intrinsic OER activity under acidic or near-neutral condition was deciphered to be identical by adjusting this pH mismatching. This result indicates that the local pH effect at the electrified solid-liquid interface plays the main role in the "fake" OER performance.
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