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Irinotecan hydrochloride liposome HR070803 in combination with 5-fluorouracil and leucovorin in locally advanced or metastatic pancreatic ductal adenocarcinoma following prior gemcitabine-based therapy (PAN-HEROIC-1): a phase 3 trial.
Signal Transduct Target Ther
September 2024
Oncology Department and State Key Laboratory of Systems Medicine for Cancer of Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Article Synopsis
- Liposomal irinotecan (HR070803) combined with 5-fluorouracil and leucovorin shows enhanced overall survival in patients with advanced pancreatic cancer previously treated with gemcitabine-based therapies, as demonstrated in a phase 3 study.
- The trial involved 298 patients, showing a median overall survival of 7.4 months for the HR070803 group compared to 5.0 months for the placebo group, with statistically significant results.
- While there were some adverse events, such as increased liver enzyme levels and decreased white blood cell counts, the safety profile was manageable, with no treatment-related deaths in the HR070803 group, highlighting its potential as a second-line treatment option for this patient
The heroic deaths of 19th century sled dogs in the Canadian Arctic.
Can Vet J
August 2024
Dr. Whitney is a retired veterinarian living in St. John's, Newfoundland. He worked for 30 years as the Chief Veterinary Officer for Newfoundland and Labrador. In addition to being a veterinarian, he also has an MA in History. This article is extracted from his current project, a book titled: Inter canem et lupum: A Distracted History of Rabies in Newfoundland and Labrador.
Let's make it personal: CRISPR tools in manipulating cell death pathways for cancer treatment.
Cell Biol Toxicol
July 2024
Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, 15731, Iran.
Advancements in the CRISPR technology, a game-changer in experimental research, have revolutionized various fields of life sciences and more profoundly, cancer research. Cell death pathways are among the most deregulated in cancer cells and are considered as critical aspects in cancer development. Through decades, our knowledge of the mechanisms orchestrating programmed cellular death has increased substantially, attributed to the revolution of cutting-edge technologies.
View Article and Find Full Text PDFSociodemographic and Health Characteristics of Hispanic Veteran Patients With Traumatic Brain Injury and Its Association to Mortality: A Pilot Study.
Mil Med
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VA Caribbean Health Care System, Research and Development Service, Nuclear Medicine and Molecular Imaging Research Section, San Juan, PR 00921, USA.
Introduction: Traumatic brain injury (TBI) is among the most common conditions in the military. VA Caribbean Healthcare System (VACHS) patients with Traumatic Brain Injury (TBI) have a higher mortality rate than Veterans in other VA health care systems in the United States. The main goal of this study was to develop sociodemographic profiles and outline health characteristics of Hispanic patients with TBI treated at the VA Caribbean Healthcare System in a search for potential explanations to account for the higher mortality rate.
View Article and Find Full Text PDFA Marginalized Zero-Inflated Negative Binomial Model for Spatial Data: Modeling COVID-19 Deaths in Georgia.
Biom J
July 2024
Division of Biostatistics, Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Spatial count data with an abundance of zeros arise commonly in disease mapping studies. Typically, these data are analyzed using zero-inflated models, which comprise a mixture of a point mass at zero and an ordinary count distribution, such as the Poisson or negative binomial. However, due to their mixture representation, conventional zero-inflated models are challenging to explain in practice because the parameter estimates have conditional latent-class interpretations.
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