AI Article Synopsis
- A study explored the relationship between constipation, frailty, and changes in gut microbiota in elderly participants, aiming to identify unique microbial signatures.
- Stool samples from 61 individuals were analyzed, revealing that constipated elders with frailty had less diverse gut microbiomes compared to those without frailty and healthy subjects.
- The research identified specific biomarkers and pathways related to vitamin B12 synthesis that were lower in frail constipated individuals, highlighting the potential for these microbial differences in diagnostics and treatments.
Article Abstract
Constipation and frailty are associated with intestinal dysbiosis. This study aims to identify intestinal microbial signatures that can differentiate between constipated elders accompanied by frailty and those without frailty. We collected stool samples from 61 participants and conducted 16S rRNA gene sequencing. Constipated patients with frailty (Constipation_F) exhibited reduced gut microbial diversities compared to constipated patients without frailty (Constipation_NF) and healthy individuals (C). From differential genera, random forest models identified 14, 8, and 5 biomarkers for distinguishing Constipation_F from Constipation_NF, Constipation_F from C, and Constipation_NF from C, respectively. Functional analysis revealed that pathways (P381-PWY and PWY-5507) related to vitamin B12 synthesis were reduced in Constipation_F, which aligns with the decreased abundances of vitamin-B12-producing and in this group. Our study unveils substantial differences in gut microbiota between constipated elders with frailty and those without, underscoring the diagnostic and therapeutic potential of genera involved in vitamin B12 synthesis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11292359 | PMC |
| http://dx.doi.org/10.1016/j.isci.2024.110403 | DOI Listing |
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Article Synopsis
- A study explored the relationship between constipation, frailty, and changes in gut microbiota in elderly participants, aiming to identify unique microbial signatures.
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- The research identified specific biomarkers and pathways related to vitamin B12 synthesis that were lower in frail constipated individuals, highlighting the potential for these microbial differences in diagnostics and treatments.
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