AI Article Synopsis
- This study examined the benefits of intensity-modulated proton therapy (IMPT) over volumetric modulated arc therapy (VMAT) in reducing the effective dose to circulating immune cells (EDIC) in patients with mediastinal Hodgkin lymphoma (mHL) after chemotherapy.! -
- Ten mHL patients were analyzed, revealing that IMPT significantly lowered the median EDIC from 1.93 Gy with VMAT to 1.08 Gy with IMPT, highlighting a notable reduction in radiation exposure.! -
- The reduction in EDIC was primarily attributed to decreased integral dose to the body and better lung protection with IMPT, indicating a potential advantage for this treatment in improving patient outcomes in cancer therapy.!
Article Abstract
Purpose: Effective dose to circulating immune cells (EDIC) is associated with survival in lung and esophageal cancer patients. This study aimed to evaluate the benefit of intensity-modulated proton therapy (IMPT) for EDIC reduction compared with volumetric modulated arc therapy (VMAT) in mediastinal Hodgkin lymphoma (mHL) patients.
Materials And Methods: Ten consecutive mHL patients treated with involved-site IMPT after frontline chemotherapy were included. The mean dose to the heart, lung, and liver and the integral dose to the body were obtained, and we calculated EDIC based on these variables. The effective dose to circulating immune cells was compared between IMPT and VMAT schedules.
Results: The median EDIC was reduced from 1.93 Gy (range: 1.31-3.87) with VMAT to 1.08 Gy (0.53-2.09) with IMPT ( < .01). Integral dose reduction was the main driver of EDIC reduction with IMPT, followed by lung sparing.
Conclusion: Intensity-modulated proton therapy significantly reduced EDIC in mHL patients undergoing consolidation involved-site radiation therapy. Integral dose reduction combined with improved lung sparing was the main driver of EDIC reduction with IMPT.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11293511 | PMC |
| http://dx.doi.org/10.1016/j.ijpt.2024.100110 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!