Genomic sequence of HLA-DQB1*03:01:01:60, -DQB1*03:01:01:61, -DQB1*03:01:01:62, -DQB1*03:01:01:63, -DQB1*03:02:01:23, -DQB1*03:02:01:24, -DQB1*03:02:01:25 and -DQB1*03:03:02:14 alleles in Spanish individuals.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/tan.15634 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Interchain disulfide engineering enables the efficient production of functional HLA-DQ-Fc fusion proteins.
J Biol Chem
September 2024
Antiger Therapeutics Inc., St Louis, Missouri, USA. Electronic address:
HLA-DQ molecules drive unwanted alloimmune responses after solid-organ transplants and several autoimmune diseases, including type 1 diabetes and celiac disease. Biologics with HLA molecules as part of the design are emerging therapeutic options for these allo- and autoimmune conditions. However, the soluble α and β chains of class II HLA molecules do not dimerize efficiently without their transmembrane domains, which hinders their production.
View Article and Find Full Text PDFDistinct HLA associations with autoantibody-defined subgroups in idiopathic inflammatory myopathies.
EBioMedicine
October 2023
Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden. Electronic address:
Background: In patients with idiopathic inflammatory myopathies (IIM), autoantibodies are associated with specific clinical phenotypes suggesting a pathogenic role of adaptive immunity. We explored if autoantibody profiles are associated with specific HLA genetic variants and clinical manifestations in IIM.
Methods: We included 1348 IIM patients and determined the occurrence of 14 myositis-specific or -associated autoantibodies.
Multiethnic genome-wide and HLA association study of total serum IgE level.
J Allergy Clin Immunol
December 2021
Department of Medicine, University of Colorado, Aurora, Colo. Electronic address:
Background: Total serum IgE (tIgE) is an important intermediate phenotype of allergic disease. Whole genome genetic association studies across ancestries may identify important determinants of IgE.
Objective: We aimed to increase understanding of genetic variants affecting tIgE production across the ancestry and allergic disease spectrum by leveraging data from the National Heart, Lung and Blood Institute Trans-Omics for Precision Medicine program; the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA); and the Atopic Dermatitis Research Network (N = 21,901).
Unopposed IL-36 Activity Promotes Clonal CD4 T-Cell Responses with IL-17A Production in Generalized Pustular Psoriasis.
J Invest Dermatol
June 2018
Department of Dermatology and Allergology, University Hospital, Ludwig-Maximilian-University, Munich, Germany. Electronic address:
Generalized pustular psoriasis (GPP) is the most severe psoriasis variant. Mutations in the IL-36 antagonist IL36RN, in CARD14 or AP1S3 provide genetic evidence for autoinflammatory etiology but cannot explain its pathogenesis completely. Here we demonstrate that unopposed IL-36 signaling promotes antigen-driven and likely pathogenic T-helper type 17 (Th17) responses in GPP.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!