AI Article Synopsis
- The study investigates how specific regenerative genes from highly regenerative organisms can affect low regenerative animals, focusing on Drosophila.
- Researchers found that while these genes hinder tissue regeneration in the developing wings, they enhance lifespan and intestinal stem cell activity in older flies.
- The results indicate that introducing these genes can lead to better stem cell functionality and improved health during aging, showing potential for regenerative medicine applications.*
Article Abstract
Background: The remarkable regenerative abilities observed in planarians and cnidarians are closely linked to the active proliferation of adult stem cells and the precise differentiation of their progeny, both of which typically deteriorate during aging in low regenerative animals. While regeneration-specific genes conserved in highly regenerative organisms may confer regenerative abilities and long-term maintenance of tissue homeostasis, it remains unclear whether introducing these regenerative genes into low regenerative animals can improve their regeneration and aging processes.
Results: Here, we ectopically express highly regenerative species-specific JmjC domain-encoding genes (HRJDs) in Drosophila, a widely used low regenerative model organism. Surprisingly, HRJD expression impedes tissue regeneration in the developing wing disc but extends organismal lifespan when expressed in the intestinal stem cell lineages of the adult midgut under non-regenerative conditions. Notably, HRJDs enhance the proliferative activity of intestinal stem cells while maintaining their differentiation fidelity, ameliorating age-related decline in gut barrier functions.
Conclusions: These findings together suggest that the introduction of highly regenerative species-specific genes can improve stem cell functions and promote a healthy lifespan when expressed in aging animals.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11295675 | PMC |
| http://dx.doi.org/10.1186/s12915-024-01956-4 | DOI Listing |
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