AI Article Synopsis
- - The study examined the potential of tertiary lymphoid structures (TLS) as indicators of prognosis in patients with penile squamous cell carcinoma (SCC) by analyzing data from 83 cases.
- - Researchers reviewed tumor slides to assess TLS density and used survival analysis to evaluate the impact of clinical factors such as BMI, tumor (T), node (N), and metastasis (M) on overall survival.
- - Results suggest that TLS could serve as a positive prognostic marker, and combining it with other clinical parameters (BMI, T, N, M) leads to improved accuracy in predicting patient outcomes, achieving high predictive values.
Article Abstract
Background: We investigated the feasibility of the tertiary lymphoid structure (TLS) as a prognostic marker for penile squamous cell carcinoma(SCC).
Methods: We retrospectively collected data from 83 patients with penile squamous cell carcinoma. H&E-stained slides were reviewed for TLS density. In addition, clinical parameters were analyzed, the prognostic value of these parameters on overall survival (OS) was evaluated using ‒ Kaplan-Meier survival curves, and the prognostic value of influencing factors was evaluated using Cox multifactor design nomogram analysis.
Result: BMI, T, N, and M are significant in the survival curve with or without tertiary lymphoid structure. BMI, T, N, M and TLS were used to construct a prognostic model for penile squamous cell carcinoma, and the prediction accuracy reached a consensus of 0.884(0.835-0.932), and the decision consensus reached 0.581(0.508-0.655).
Conclusion: TLS may be a positive prognostic factor for penile squamous cell carcinoma, and the combination of BMI, T, N and M can better evaluate the prognosis of patients.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11295339 | PMC |
| http://dx.doi.org/10.1186/s12894-024-01532-6 | DOI Listing |
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