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Lactic acidosis with metformin accumulation in the intensive care units of the Nord Pas de Calais region: A known serious adverse event that can be better prevented.
Therapie
December 2024
CHU Lille, University Lille, Intensive Médecine Reanimation, 59000 Lille, France.
Article Synopsis
- The study focused on identifying situations that lead to metformin-associated lactic acidosis (MALA) in ICU patients and evaluating its preventability.
- A total of 198 MALA cases were assessed, with 19.2% resulting in death; the majority of patients had acute events like dehydration or severe infections that contributed to the condition.
- The findings indicated that MALA is often preventable, highlighting the need for better physician and patient education regarding metformin use during high-risk medical situations.
[Lactic acidosis associated with metformin: A case series from the Saint-Denis hospital].
Rev Med Interne
January 2025
Service de médecine interne, hôpital Louis-Mourier, Colombes, France.
Introduction: Metformin is a first line treatment for type II diabetes. Cases of metformin-associated lactic acidosis are regularly reported. A direct causal link between metformin overdose and lactic acidosis is not clearly established.
View Article and Find Full Text PDFSimultaneous Treatment of Two Severe Acute Intoxication and Acute Kidney Injury.
Semin Dial
December 2024
Nephrology, Dialysis and Kidney Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Extracorporeal therapies could be required for treatment of life-threatening severe acute intoxication. We present the case of an 82-year-old patient admitted to our Nephrology Unit because of metformin-associated lactic acidosis (MALA) and acute kidney injury (AKI stage III AKIN criteria). The patient also presented severe intoxication of digoxin and apixaban.
View Article and Find Full Text PDF[Acute blindness in a patient with metformin-associated lactic acidosis].
Ned Tijdschr Geneeskd
October 2024
Zaans Medisch Centrum, afd. Interne Geneeskunde, Zaandam.
Lactic acidosis is a rare metabolic complication that can occur in patients with diabetes mellitus type 2 who use metformin. We discuss a 79-year old woman with metformin-associated lactic acidosis (MALA) and acute kidney injury based on gastroenteritis. Patient reported acute blindness which in literature is described as a rare presentation of a metabolic acidosis (regardless of its underlying cause).
View Article and Find Full Text PDFTrends in Antidiabetic Drug Use and Safety of Metformin in Diabetic Patients with Varying Degrees of Chronic Kidney Disease from 2010 to 2021 in Korea: Retrospective Cohort Study Using the Common Data Model.
Pharmaceuticals (Basel)
October 2024
Department of Regulatory Science, College of Pharmacy, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
Article Synopsis
- The study aimed to analyze trends in the use of antidiabetic medications in patients with chronic kidney disease (CKD) and identify the risk of metformin-associated lactic acidosis (MALA).
- It involved a review of electronic medical records from 2010 to 2021, focusing on patients over 18 with both CKD and type 2 diabetes who had been on antidiabetic drugs for at least 30 days.
- Metformin was the most commonly prescribed drug for earlier stages of CKD, but its use declined significantly in advanced stages, while SGLT2 and DPP-4 inhibitors saw increased prescriptions, highlighting varying treatment patterns and low MALA risk in CKD patients.
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