AI Article Synopsis
- Insecticide resistance is complicated, and a new study focuses on how the chemosensory system contributes to this resistance, specifically looking at a gene called RpCSP6 and its interaction with the insecticide deltamethrin.
- The study shows that RpCSP6 is present in various tissues and developmental stages and can be induced by deltamethrin; when this gene is knocked down, insects become more vulnerable to the insecticide.
- Key findings include the identification of seven important residues that interact with deltamethrin, which can help in developing more effective insecticides that target insect chemosensory proteins (CSPs).
Article Abstract
The mechanisms of insecticide resistance are complex. Recent studies have revealed a novel mechanism involving the chemosensory system in insecticide resistance. However, the specific binding mechanism between olfactory-related genes and insecticides needs to be clarified. In this study, the binding mechanism between pyrethroid insecticide deltamethrin and RpCSP6 from was investigated by using computational and multiple experimental methods. was expressed in different tissues and developmental stages of and can be induced by deltamethrin. Knockdown of significantly increased the susceptibility of to deltamethrin. The binding affinity of RpCSP6 to 24 commonly used insecticides was measured. Seven key residues were found to steadily interact with deltamethrin, indicating their significance in the binding affinity to the insecticide. Our research provided insights for effectively analyzing the binding mechanism of insect CSPs with insecticides, facilitating the development of new and effective insecticides that target insect CSPs.
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| http://dx.doi.org/10.1021/acs.jafc.4c03368 | DOI Listing |
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