AI Article Synopsis
- FTD is a rising area of research as it is the second leading cause of early-onset dementia, and this study analyzed bibliometric trends from 2000 to 2022.
- A total of 10,227 papers were reviewed, highlighting a dramatic increase in FTD research, primarily published in the Journal of Alzheimer's Disease, with notable contributions from the U.S. and the University of California San Francisco.
- Key research areas include clinical diagnostics and pathological mechanisms involving proteins and genetic factors, with future directions focusing on biomarker development for better diagnosis.
Article Abstract
Background: Frontotemporal dementia (FTD) is a neurodegenerative disease with clinical, pathological, and genetic heterogeneity. FTD is receiving increasing attention because it is the second leading cause of early-onset dementia after Alzheimer's disease. This study aimed to analyse the research trends and hotspots of FTD from 2000 to 2022 using bibliometrics.
Methods: Papers related to FTD from 2000 to 2020 were systematically searched through the Web of Science Core Collection (WOSCC). Citespace and Vosviewer software were used to visually analyse the retrieved data of countries/regions, institutions, journals, authors, references, and keywords. Microsoft Excel was used to generate the annual publications and growth trends.
Results: There were 10,227 papers included in the bibliometric analysis. The annual publication output on FTD has increased significantly from 2000 to 2022, with papers published in 934 academic journals and 87 countries/regions. The Journal of Alzheimer's Disease was the most popular, with 488 papers about FTD. The most productive countries/regions, institutions, and authors are the United States ( = 4,037), the University of California San Francisco ( = 687), and Miller, Bruce L. ( = 427), respectively. The article by Katya Rascovsky and her colleagues published on Brain in 2011 was the most cocited paper, with 625 citations. The research hotspots in this field were the clinical diagnostic criteria, subdivision, and pathological mechanism of FTD, such as tau protein, chromosome 17, progranulin, TDP-43, and C9orf72.
Conclusion: The future research direction is based on biomarkers and pathological mechanisms to diagnose and differential diagnose FTD from the aspects of behavior, neuropathology, neuroimaging, and serum markers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11288951 | PMC |
| http://dx.doi.org/10.3389/fneur.2024.1399600 | DOI Listing |
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