AI Article Synopsis
- The study aimed to evaluate the efficacy of topical vasodilators (Nitroglycerin, Papaverine, Magnesium sulfate) against a control group for reducing vasospasm during microsurgical anastomosis in rats.
- In a randomized experiment with 15 rats, only magnesium sulfate at 10% demonstrated a significant increase in arterial diameter compared to the control after 10 minutes.
- The conclusion suggests that magnesium sulfate is a more effective and cost-efficient vasodilator for arterial procedures in microsurgery compared to the other drugs tested, highlighting its potential for clinical use.
Article Abstract
Objective: Throughout microsurgical anastomosis, many surgeons use topical vasodilators in order to reduce pathological vasospasm. It was carried out an experimental study comparing the effectiveness of topical use of Nitroglycerin, Papaverine, Magnesium sulfate over a control group in the femoral artery and vein of rats, in reducing prolonged vasospasm.
Methods: Randomized comparative experimental study in 15 rats, divided into four groups. The external diameter of the vases soaked in the randomized solution was measured. For statistical analysis, it was calculated the percentual increase in the external diameter of the vessels.
Results: A statistically significant increase in arterial dilation was observed after 10 minutes of topical application of 10% magnesium sulfate compared to the control group, with . No other drug showed a vasodilator effect superior to the control group. Magnesium sulfate at 10% is still not used in microsurgery and costs 15 times less than papaverine, the standard drug for topical vasodilation in clinical cases at our service.
Conclusion: Magnesium sulfate had better vasodilating effects over the control group after 10 minutes of arterial microanastomosis. None of the tested drugs have presented superior vasodilating effects over each other nor the control group after venous microanastomosis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11288313 | PMC |
| http://dx.doi.org/10.1590/1413-785220243203e276513 | DOI Listing |
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