AI Article Synopsis
- Immunotherapy has significantly advanced cancer treatment, but long-term survival for colorectal cancer patients is still a major challenge.
- Combination treatments using targeted drugs like MEK inhibitors have provided some relief, but more effective therapies are needed.
- Recent interest is growing in innovative methods, such as light-activated drugs and optical devices, which could enable precise delivery of cancer-fighting agents directly to tumor cells in the colon.
Article Abstract
Over the years immunotherapy has demonstrably improved the field of cancer treatment. However, achieving long-term survival for colorectal cancer (CRC) patients remains a significant unmet need. Combination immunotherapies incorporating targeted drugs like MEK or multi-kinase inhibitors have offered some palliative benefit. Nevertheless, substantial gaps remain in the current therapeutic armamentarium for CRC. In recent years, there has been a surge of interest in exploring novel treatment strategies, including the application of light-activated drugs in conjunction with optical devices. This approach holds promise for achieving localized and targeted delivery of cytotoxic agents, such as microtubule-targeting drugs, directly to cancerous cells within the colon.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287401 | PMC |
| http://dx.doi.org/10.3748/wjg.v30.i26.3257 | DOI Listing |
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