AI Article Synopsis
- * The study found that levels of the 5-HT receptor increased with age and inversely correlated with LFS-LTD magnitude, suggesting the 5-HT receptor plays a role in this process.
- * Manipulating the 5-HT receptor in knockout or pharmacological ways affected LFS-LTD in adult and adolescent mice, with implications for understanding LTD at the cellular level and potential treatments for psychiatric disorders.
Article Abstract
NMDA receptor-dependent long-term depression (LTD) in the hippocampus is a well-known form of synaptic plasticity that has been linked to different cognitive functions. Although the underlying mechanisms remain unclear, this form of LTD cannot be induced by low-frequency stimulation (LFS) in adult mice. In this study, we found that LFS-induced LTD was not easily induced in adult animals and was age dependent. Interestingly, the level of the 5-HT receptor was correspondingly increased and exhibited an inverse correlation with the magnitude of LFS-LTD during development. Knockout or pharmacological inhibition of the 5-HT receptor reversed impaired LFS-LTD in adult mice (P60), while activation or inhibition of this receptor disturbed or enhanced LFS-LTD in adolescent mice (P21), respectively. Furthermore, the astrocytic 5-HT receptor in the hippocampus predominantly mediated age-dependent LFS-LTD through enhancing GABAergic neurotransmission. Finally, fear memory extinction differed among the above conditions. These observations enrich our knowledge of LTD at the cellular level and suggest a therapeutic approach for LTD-related psychiatric disorders.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371825 | PMC |
| http://dx.doi.org/10.1038/s12276-024-01285-0 | DOI Listing |
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