AI Article Synopsis
- A 76-year-old woman with ongoing diarrhea was hospitalized and found to have purpura, high eosinophil levels, and elevated IgG4 antibodies.
- CT scans showed large amounts of fluid in her abdomen and swelling in her intestines.
- Skin and gastrointestinal biopsies confirmed eosinophilic gastroenteritis and leukocytoclastic vasculitis but didn't meet criteria for IgG4-related disease, suggesting the connection between eosinophilic gastroenteritis and IgG4-related disease needs more research.
Article Abstract
A 76-year-old woman with persistent diarrhea was referred to our hospital. She had purpura, peripheral eosinophilia (18,177/μL), and an elevated serum IgG4 level (819 mg/dL). Abdominal computed tomography revealed massive ascites and bowel edema. A skin biopsy of the purpura revealed leukocytoclastic vasculitis with prominent eosinophilic infiltration. Biopsies of the gastrointestinal mucosa revealed dense eosinophilic infiltration, indicating eosinophilic gastroenteritis (EG) associated with the hypereosinophilic syndrome. The number of IgG4-positive cells increased in the duodenal mucosa; however, the diagnostic criteria for IgG4-related disease (IgG4-RD) were not met. Whether or not EG with ascites is a manifestation of IgG4-RD warrants further investigation.
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| http://dx.doi.org/10.2169/internalmedicine.3769-24 | DOI Listing |
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