Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bbrc.2024.150454 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Insights into NEK2 inhibitors as antitumor agents: From mechanisms to potential therapeutics.
Eur J Med Chem
January 2025
Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Healthand, Department of Frontiers Science Center for Disease-related Molecular Network, Core Facilities, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. Electronic address:
NEK2, a serine/threonine protein kinase, is integral to mitotic events such as centrosome duplication and separation, microtubule stabilization, spindle assembly checkpoint, and kinetochore attachment. However, NEK2 overexpression leads to centrosome amplification and chromosomal instability, which are significantly associated with various malignancies, including liver, breast, and non-small cell lung cancer. This overexpression could facilitate tumor development and confer resistance to therapy by promoting aberrant cell division and centrosome amplification.
View Article and Find Full Text PDFStructural and Functional Remodeling for Elite Cyclists During Exercise; Pressure Volume Loops and Hemodynamic Forces Analysis.
Am J Physiol Heart Circ Physiol
January 2025
Sport Medicine Unit, Careggi University Hospital, Via delle Oblate 4, 50134 Florence, Italy.
The study was designed to investigate the pattern of intraventricular Hemo-Dynamic Forces (HDF) and myocardial performance during exercise in Elite Cyclists (EC). Transthoracic stress echocardiography was performed on nineteen EC and thirteen age-matched sedentary controls (SC) at three incremental exercise intensities based on Heart Rate Reserve (HRR). Left Ventricular (LV) HDF were computed from echocardiography long-axis data sets using a novel technique based on endocardial boundary tracking, both in apex-base and latero-septal directions.
View Article and Find Full Text PDFAnalysis of "Dr Ding Xiang" on WeChat in China to Determine Factors Influencing Readership on Medical Social Media: Observational Study.
J Med Internet Res
January 2025
Department of Epidemiology, School of Public Health, Sun Yat-Sen University, Shenzhen, China.
Background: With the rapid expansion of social media platforms, the demand for health information has increased substantially, leading to innovative approaches and new opportunities in health education.
Objective: This study aims to analyze the characteristics of articles published on the "Dr Ding Xiang" WeChat official account (WOA), one of the most popular institutional accounts on the WeChat platform, to identify factors influencing readership engagement and to propose strategies for enhancing the effectiveness of health information dissemination.
Methods: A total of 5286 articles published on the "Dr Ding Xiang" WOA from January 2021 to December 2021 were collected and analyzed.
Isoreticular Tolerance and Phase Selection in the Synthesis of Multi-Module Metal-Organic Frameworks for Gas Separation and Electrocatalytic OER.
Angew Chem Int Ed Engl
January 2025
University of California Riverside, Chemistry Department, Chemistry Department, 92521, Riverside, UNITED STATES OF AMERICA.
Although metal-organic frameworks are coordination-driven assemblies, the structural prediction and design using metal-ligand interactions can be unreliable due to other competing interactions. Leveraging non-coordination interactions to develop porous assemblies could enable new materials and applications. Here, we use a multi-module MOF system to explore important and pervasive impact of ligand-ligand interactions on metal-ligand as well as ligand-ligand co-assembly process.
View Article and Find Full Text PDFHighly salt-resistant and efficient dynamic Janus absorber based on thermo-responsive hydroxypropyl cellulose.
Mater Horiz
January 2025
School of Materials Science and Engineering, National Institute for Advanced Materials, Nankai University, Tianjin 300350, China.
Recent advances in interfacial solar steam generation have made direct solar desalination a promising approach for providing cost-effective and environmentally friendly clean water solutions. However, developing highly effective, salt-resistant solar absorbers for long-term desalination at high efficiencies and evaporation rates remains a significant challenge. We present a Janus hydrogel-based absorber featuring a surface modified with thermo-responsive hydroxypropyl cellulose (HPC) and a hydrogel matrix containing photothermal conversion units, MXene, specifically designed for long-term seawater desalination.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!