Itraconazole (ITZ) is one of the broad-spectrum antifungal agents for treating fungal keratitis. In clinical use, ITZ has problems related to its poor solubility in water, which results in low bioavailability when administered orally. To resolve the issue, we formulated ITZ into the inclusion complex (ITZ-IC) system using β-cyclodextrin (β-CD), which can potentially increase the solubility and bioavailability of ITZ. The molecular docking study has confirmed that the binding energy of ITZ with the β-CD was -5.0 kcal/mol, indicating a stable conformation of the prepared inclusion complex. Moreover, this system demonstrated that the inclusion complex could significantly increase the solubility of ITZ up to 4-fold compared to the pure drug. Furthermore, an ocular drug delivery system was developed through dissolving microneedle (DMN) using polyvinyl pyrrolidone (PVP) and polyvinyl alcohol (PVA) as polymeric substances. The evaluation results of DMN inclusion complexes (ITZ-IC-DMN) showed excellent mechanical strength and insertion ability. In addition, ITZ-IC-DMN can dissolve rapidly upon application. The permeation study revealed that 75.71% (equivalent to 3.79 ± 0.21 mg) of ITZ was permeated through the porcine cornea after 24 h. Essentially, ITZ-IC-DMN exhibited no signs of irritation in the HET-CAM study, indicating its safety for application. In conclusion, this study has successfully developed an inclusion complex formulation containing ITZ using β-CD in the DMN system. This approach holds promise for enhancing the solubility and bioavailability of ITZ through ocular administration.
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http://dx.doi.org/10.1080/09205063.2024.2380129 | DOI Listing |
BMC Pregnancy Childbirth
December 2024
Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China.
Purpose: This study aimed to identify novel biomarkers for preeclampsia (PE) diagnosis by integrating Weighted Gene Co-expression Network Analysis (WGCNA) with machine learning techniques.
Patients And Methods: We obtained the PE dataset GSE25906 from the gene expression omnibus (GEO) database. Analysis of differentially expressed genes (DEGs) and module genes with Limma and Weighted Gene Co-expression Network analysis (WGCNA).
BMC Public Health
December 2024
Department of Public Health and Caring Sciences, Uppsala University, Box 564, Uppsala, SE-751 22, Sweden.
Background: The return-to-work (RTW) process for individuals on long-term sick leave can be complex. Vocational rehabilitation may facilitate RTW; however, many intervention studies often have relatively short follow-up periods. The purpose of this study was to assess long-term work participation 2-7 years after the initiation of a three-armed randomized controlled trial aimed at RTW for individuals on long-term sick leave because of mental disorders and/or chronic pain.
View Article and Find Full Text PDFInt J Med Inform
December 2024
Northeastern University, 360 Huntington Ave, Boston, MA 02115, United States. Electronic address:
Objectives: Artificial Intelligence (AI) and Machine Learning (ML) have emerged as transformative technologies across various industries, including healthcare, biotechnology, and vaccine development. These technologies offer immense potential to improve project management efficiency, decision-making, and resource utilization, especially in complex tasks such as vaccine development and healthcare innovations.
Methods: A systematic meta-analysis was conducted by reviewing studies from databases like PubMed, IEEE Xplore, Scopus, Web of Science, EMBASE, and Google Scholar until September 2024.
Eval Program Plann
December 2024
Malaviya National Institute of Technology Jaipur, Rajasthan, India. Electronic address:
This research examines the challenges and opportunities in implementing Digital Literacy Training Programs (DLTPs) in rural areas of India, focusing on bridging the digital divide. Drawing on Standpoint Theory, the study explores how stakeholders' social locations and identities shape their perspectives on DLTPs, highlighting power dynamics and intersectionality within program implementation. Through qualitative analysis, including interviews with district-level managers, trainers, trainees, and potential beneficiaries, the study uncovers critical challenges such as infrastructural issues, limited access to digital resources, and perceived usefulness barriers.
View Article and Find Full Text PDFCarbohydr Res
December 2024
Department of Physics, Rayat Shikshan Sanstha's Dada Patil Mahavidyalaya, Karjat, Dist - Ahemadnagar, M.S. 414 402, India.
The discovery of branched molecules like dextrin by Schardinger in 1903 marked the inception of cyclodextrin (CD) utilization, catalyzing its journey from laboratory experimentation to widespread commercialization within the pharmaceutical industry. CD, a cyclic oligosaccharide containing glucopyranose units, acts as a versatile guest molecule, forming inclusion complexes (ICs) with various host molecules. Computational studies have become instrumental in elucidating the intricate interactions between β-CD and guest molecules, enabling the prediction of binding energy, forces, affinity, and complex stability.
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