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Anti-Inflammatory Potential and Synergic Activities of (L.) L. Leaf-Derived Ointment Formulation in Combination with the Non-Steroidal Anti-Inflammatory Drug Diclofenac in Suppressing Atopic Dermatitis (AD).
Life (Basel)
December 2024
Department of Basic Medical Sciences, College of Medicine, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
Atopic dermatitis (AD) or eczema is an important inflammatory chronic skin disease that brings many complications in its management and treatment. Although several chemical agents are used for treatment, the search for better anti-inflammatory and antibacterial agents of plant origin has been ongoing, since natural compounds, it is commonly believed, are less dangerous than synthetic ones. Therefore, the present study explored a medicinal plant- (L.
View Article and Find Full Text PDFSuspect screening and quantitative analysis of 165 contaminants of emerging concern in water, sediments, and biota using LC-MS/MS: Ecotoxicological and human health risk assessment.
Sci Total Environ
February 2025
Federal University of Santa Catarina, Agricultural Sciences Center, Department of Food Science and Technology, Brazil. Electronic address:
This study aimed to implement a targeted multiple reaction monitoring (MRM) screening strategy using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) for the initial detection of 165 compounds of emerging concern (CECs) in water, sediment, and fish samples. Following the screening, confirmatory and quantitative analyses were conducted using analytical standards for the detected compounds. Qualitative results were confirmed using high-resolution mass spectrometry (HRMS) for those CECs without available standards.
View Article and Find Full Text PDFAssociating regulatory actions on diclofenac use with Danish trends in utilization by route of administration 1999-2023.
Pharmacotherapy
January 2025
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Aims: With the growing evidence of cardiovascular risks associated with diclofenac use, regulatory measures governing its application and sales have intensified since 2008. We evaluated the association between central regulatory actions and trends in diclofenac use in Denmark from 1999 to 2023, according to different dosage forms and routes of administration.
Methods And Results: Data on diclofenac sales in Denmark from 1999 to 2023 were retrieved from the publicly available web database MEDSTAT, based on the Danish Register of Medicinal Products Statistics.
Simulation-based process optimization of full-scale advanced wastewater treatment systems using powdered activated carbon.
Water Sci Technol
December 2024
University of Kassel, Chair of Urban Water Engineering, Kurt-Wolters-Street 3, Kassel 34125, Germany E-mail:
This study extends a previously developed competitive modeling approach for predicting the adsorption of organic micropollutants (OMPs) on powdered activated carbon (PAC) in full-scale advanced wastewater treatment. The approach incorporates adsorption analysis for organic matter fractionation, assumes pseudo-first order kinetics and differentiates between fresh and partially loaded PAC through fraction segregation. Validation through full-scale measurement campaigns reveals successful model predictions of OMP removal, underestimating, however, diclofenac removals by 15-20%.
View Article and Find Full Text PDFENHANCED RECOVERY AFTER CAESAREAN SECTION - AN IMPROVED PATHWAY THAN CONVENTIONAL CARE FOR REDUCING HOSPITAL STAY.
J Ayub Med Coll Abbottabad
November 2024
Department of Gynaecology and Obstetrics, Police Hospital Karachi-Pakistan.
Background: With the help of an evidence-based approach called "Enhanced Recovery After Surgery" (ERAS), patients can receive standardised perioperative care and recover more quickly. Many surgical specialities, such as orthopaedics, gynaecological onco-surgery, breast surgery, urology, and colorectal surgery, use ERAS protocols extensively. Improved postoperative recovery is beneficial in lowering hospital stays, and costs, and increasing patient satisfaction.
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