Comment on "Dynamics and rheology of vesicles under confined Poiseuille flow" by Z. Gou, H. Zhang, A. Nait-Ouhra, M. Abbasi, A. Farutin and C. Misbah, , 2023, , 9101. | LitMetric
In a recent paper, [Gou , , 2023, , 9101-9114] studied numerically the viscosity of a confined suspension of vesicles flowing in a channel as a function of vesicle concentration. In order to discuss the genericity of the observed behaviour, namely a nearly constant effective viscosity at low concentrations, we complement their study by a comparison with the few existing ones in the literature. In particular, we highlight that they fail to reproduce well established results for blood viscosity in microcirculation, thereby suggesting that the conclusions regarding the optimization of cell transport and oxygenation may not apply. We conclude with a quick discussion on potential improvements regarding numerical modeling, as long as physiological relevance is sought.
All-atom molecular dynamics (AAMD) is a computational technique that predicts the movement of particles based on the intermolecular forces acting on the system. It enables the study of biological systems at atomic detail, complements observations from experiments, and can help the selection of experimental targets. Here, we describe the applications of MD simulations to study the interaction between peripheral membrane proteins and lipid bilayers.
Intrinsically disordered regions (IDRs) are crucial to homeostatic and organellar remodeling pathways. In reticulophagy/ER-phagy, long cytosolic IDR-containing receptors (e.g.
This commentary article is important and relevant, as organizational culture and innovation are essential to health organization's performance and viability in a dynamic and competitive setting. Organizational culture is the unquenchable drive that propels an organization's growth and serves as its soul. However, effective internal innovation management is one way that managers and organizations may foster innovation.
The editorial by McKee and colleagues is an important call to action to put a spotlight on trust and its role in the function of health systems. The authors make a good case for this focus considering how trust in health systems seems to have eroded in recent years, an erosion accelerated by the COVID-19 pandemic. They recognize that trust is complex given the many forms of trust, the importance of context, and its dynamic and unpredictable nature.
