AI Article Synopsis
- Four new lycoctonine-type C-diterpenoid alkaloids, named kamaonensines H-K, were isolated from whole plants along with 12 previously known compounds.
- The kamaonensines feature a unique nitrone (imine N-oxide) structure that is rare in this context.
- Evaluation of compounds revealed that some exhibited strong anti-inflammatory effects, while others demonstrated significant cytotoxicity in RAW 264.7 macrophage cells.
Article Abstract
Four new lycoctonine-type C-diterpenoid alkaloids kamaonensines H-K () have been isolated from the whole plants of , together with 12 known compounds (). Interestingly, kamaonensines contained a rare nitrone (immine N-oxide) moiety, respectively. Their structures were established by spectroscopic analyses. The active evaluation of compounds () by LPS induced RAW 264.7 macrophages showed that compounds and displayed strong anti-inflammatory activities. While compounds and also showed strong cytotoxicities by the RAW 264.7 cell viability assay.
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| http://dx.doi.org/10.1080/10286020.2024.2385370 | DOI Listing |
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