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Optical single-shot readout of spin qubits in silicon.
Nat Commun
January 2025
TUM School of Natural Sciences, Department of Physics and Munich Center for Quantum Science and Technology (MCQST), Technical University of Munich, James-Franck-Str. 1, Garching, Germany.
Small registers of spin qubits in silicon can exhibit hour-long coherence times and exceeded error-correction thresholds. However, their connection to larger quantum processors is an outstanding challenge. To this end, spin qubits with optical interfaces offer key advantages: they can minimize the heat load and give access to modular quantum computing architectures that eliminate cross-talk and offer a large connectivity.
View Article and Find Full Text PDFOrthogonal and multiplexable genetic perturbations with an engineered prime editor and a diverse RNA array.
Nat Commun
December 2024
Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX, USA.
Programmable and modular systems capable of orthogonal genomic and transcriptomic perturbations are crucial for biological research and treating human genetic diseases. Here, we present the minimal versatile genetic perturbation technology (mvGPT), a flexible toolkit designed for simultaneous and orthogonal gene editing, activation, and repression in human cells. The mvGPT combines an engineered compact prime editor (PE), a fusion activator MS2-p65-HSF1 (MPH), and a drive-and-process multiplex array that produces RNAs tailored to different types of genetic perturbation.
View Article and Find Full Text PDFA modular machine learning tool for holistic and fine-grained behavioral analysis.
Behav Res Methods
December 2024
CAP Team, Centre de Recherche en Neurosciences de Lyon - INSERM U1028 - CNRS UMR 5292 - UCBL - UJM, 95 Boulevard Pinel, 69675, Bron, France.
Artificial intelligence techniques offer promising avenues for exploring human body features from videos, yet no freely accessible tool has reliably provided holistic and fine-grained behavioral analyses to date. To address this, we developed a machine learning tool based on a two-level approach: a first lower-level processing using computer vision for extracting fine-grained and comprehensive behavioral features such as skeleton or facial points, gaze, and action units; a second level of machine learning classification coupled with explainability providing modularity, to determine which behavioral features are triggered by specific environments. To validate our tool, we filmed 16 participants across six conditions, varying according to the presence of a person ("Pers"), a sound ("Snd"), or silence ("Rest"), and according to emotional levels using self-referential ("Self") and control ("Ctrl") stimuli.
View Article and Find Full Text PDFAdvances in Data Pre-Processing Methods for Distributed Fiber Optic Strain Sensing.
Sensors (Basel)
November 2024
Institute of Concrete Structures, TUD Dresden University of Technology, 01062 Dresden, Germany.
Because of their high spatial resolution over extended lengths, distributed fiber optic sensors (DFOS) enable us to monitor a wide range of structural effects and offer great potential for diverse structural health monitoring (SHM) applications. However, even under controlled conditions, the useful signal in distributed strain sensing (DSS) data can be concealed by different types of measurement principle-related disturbances: strain reading anomalies (SRAs), dropouts, and noise. These disturbances can render the extraction of information for SHM difficult or even impossible.
View Article and Find Full Text PDFReverse Sleeve Placement in Complex Total Hip Arthroplasty for a Patient with Severe Valgus Deformity of the Trochanter-Surgical Technique and Case Report.
J Orthop Case Rep
December 2024
Department of Orthopaedics, Apollo Hospitals, Bannerghatta Road, Bengaluru, Karnataka, India.
Introduction: It is rare to encounter a patient with severe valgus deformity of the greater trochanter with severe osteoarthritis of the hip joint. The treatment, that is total hip arthroplasty (THA) in such a case presents with a surgical challenge in proper placement of the femoral stem. Traditionally, an osteotomy procedure to correct the femoral deformity was warranted followed by THA.
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