AI Article Synopsis
- The study explores how high-fat diets and aging relate to the prevalence of stroke in the US, specifically looking at PhenoAge (PA) and PhenoAgeAccel (PAA).
- Using methods like correlation heatmaps and logistic regression, the researchers found significant associations between both PA and PAA with stroke prevalence.
- The results suggest that maintaining a PA below 31.6 can benefit stroke risk reduction, especially for those aged 40-80 and in overweight or obese populations, indicating PA and PAA could be useful markers for stroke prevention strategies.
Article Abstract
Background: The challenges posed by an aging society are increasingly recognized, particularly regarding the potential impacts of high-fat diets and the trend toward younger ages of disease onset. The purpose of this study was to clarify the relationships between the prevalence of stroke in the general US population and PhenoAge (PA) and PhenoAgeAccel (PAA).
Methods: Key methods included a correlation heatmap to explore linear relationships between some of the variables and weighted multivariable logistic regression to assess associations between PA, PAA, and stroke. Restricted cubic spline (RCS) analysis was used to investigate nonlinear relationships and dose-response effects. The ability of the PAA to predict stroke risk was assessed by a nomogram model and a receiver operating characteristic curve.
Results: After adjusting for confounding variables, both continuous and categorical PA and PAA were significantly associated with stroke prevalence. RCS analysis revealed a significant nonlinear relationship between PA and stroke prevalence. Further subgroup RCS analysis indicated that maintaining PA below 31.6 could provide greater benefits across all races and genders, specifically for individuals aged 40-80 years and those who are overweight or obese.
Conclusion: This study highlights the importance of stroke prevention in overweight and obese populations. Monitoring intermediary factors such as high-density lipoprotein cholesterol and waist circumference may reduce stroke risk. Additionally, PA and PAA may serve as novel markers for stroke, offering new directions for health management in an aging society.
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| http://dx.doi.org/10.1093/postmj/qgae093 | DOI Listing |
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